不同致伤原因对大鼠勃起功能障碍的影响  

Influence of different injury causes on erectile dysfunction in rats

作　　者：吴涛[1] 李敏[1] 陈宗平[1] 陈婵娟[1] 彭义娟[1] 邱兆雨[1] 梁国标[1] 崔伟[1] 简毓[1] 张能[1] 罗旭[1] 赵泽驹[1] 

机构地区：[1]遵义医学院附属医院泌尿外科,贵州遵义563099

出　　处：《重庆医学》2016年第13期1747-1749,共3页Chongqing medicine

基　　金：贵州省科技厅基金[黔科合J字LKZ(2011)07]

摘　　要：目的探讨不同组合切断雄鼠勃起神经、勃起血管及坐骨海绵体肌对勃起功能障碍（ED）的影响。方法根据切断方式不同，将285只生殖期雄性Wistar大鼠分成单侧切断A1～A7组（勃起神经；勃起血管；坐骨海绵体肌；勃起神经和血管；神经和坐骨海绵体肌；勃起血管和坐骨海绵体肌；勃起神经、勃起血管扣坐骨海绵体肌）；双侧切断B1～B3组（勃起神经；勃起血管；坐骨海绵体肌）；一侧勃起神经和对侧勃起血管组（C1组）；一侧勃起神经和对侧坐骨海绵体肌组（C2组）；一侧勃起血管和对侧坐骨海绵体肌组（C3组）；假手术组（D组），以上各组20只，健康对照组（E组，n一5）。育龄期未孕雌鼠285只，随机与上述各组--配对饲养。观察配对雌鼠受孕情况（3个月）。结果A1～A4组死亡分别为4、2、3和2只，配对雌鼠受孕率100％；A5～A7组死亡分别为4、5和4只，配对雌鼠受孕率分别为88．9％、83．3％和94．1％；B1～B3、C1～C3组死亡分别为3、2、3、2、5和5只，配对雌鼠均未受孕；D组死亡2只，配对雌鼠受孕率100％；E组无死亡，配对雌鼠受孕率100％。结论不同组合切断雄鼠同侧勃起神经、勃起血管、坐骨海绵体肌均不会导致永久性ED，不同组合切断雄鼠双侧勃起神经、勃起血管、坐骨海绵体肌均导致永久性ED。Objective To explore the influence of different combination cuttings of male rat erectile nerves, erection vessels and ischiocavernosus muscle on erectile dysfunction （ED）. Methods According to different cutting modes, 285 reproductive male Wistar rats were randomly divided into：unilateral cutting group A1--A7 （ erectile nerve, erectile vessel; ischiocavernosus muscle; erectile;nerve and ischiocavernosus muscle, erectile vessel and ischiocavernosus muscle;erectile nerve, erectile vessel and ischiocavernosus muscle）;bilateral cutting group B1-B3 （erectile nerve, erectile vessel and ischiocavernosus muscle） ;unilateral erectile nerve and eontralateral erectile vessel cutting group （C1） ;unilateral erectile nerve and contralateral ischiocavernosus muscle cutting group （C2） ;unilateral erectile vessel and contralateral ischiocavernosus muscle cutting group（C3） ;sham operation group （D） ,20 cases in each group,and the healthy control group（E, 5 cases）. 285 non-pregnant childbearing rats were randomly paired with the above groups for feeding. The pregnant situation（3 months） in the paired female rats was observed. Results The death in the group A1- A4 was 4,2,3 and 2 cases respectively; the pregnancy rate in paired female rats was 100 %;the death in the group A5-A7 was 4, 5 and 4 cases respectively;the pregnancy rates in paired female rats were 88.9 %,83.3% and 94.1% respectively;the death in the group B1--B3 and group C1-C3 was 3,2,3,2 and 5 cases respectively; all paired female rats were not pregnant; 2 cases in the group D died,the pregnancy rate in paired female rats was 100% ;no case in the group E died and all paired female rats were pregnant with the pregnancy rate of 100%. Conclusion Different combination cuttings of ipsilateral erectile nerves,erectile vessels and ischiocavernosus muscle do not lead to permanent ED;different combination cuttings of bilateral erectile nerves,erectile vessels and ischiocavernosus muscle lead to permanent ED.

关 键 词：勃起功能障碍 病因学 损伤 大鼠 Wistar 

分 类 号：R698[医药卫生—泌尿科学]