游泳运动与药物综合治疗大鼠慢性非细菌性前列腺炎的病理学观察  

Pathological observation on swimming exercise and medicine for comprehensive treatment of chronic abacterial prostatitis in rats

作　　者：孙海波[1] 汪敏[1] 李章春[1] 秦萍[1] 周丽琴[1] 张玉娟[1] 

机构地区：[1]黔南民族医学高等专科学校,贵州都匀558003

出　　处：《重庆医学》2016年第13期1750-1752,共3页Chongqing medicine

基　　金：黔南民族医学高等专科学校科研基金项目(QNYZ201323)

摘　　要：目的探讨游泳运动与药物综合治疗大鼠慢性非细菌性前列腺炎（CAP）的病理学改变及影响。方法健康成年SD雄性大鼠60只，随机分为空白对照组（n=12）、CAP模型对照组（n=12）、运动治疗组（n=12）、药物治疗组（n=12）及运动与药物综合治疗组（n=12）。采用消痔灵制备CAP大鼠模型。药物治疗组及综合治疗组给予相应药物灌胃治疗；运动治疗组及综合治疗组采用每天1次，每周6d，持续3周的游泳运动；空白对照组、CAP模型对照组及运动治疗组给予无菌生理盐水灌胃。分别于第4、8、11、14、18、22天取各组大鼠前列腺，计算前列腺指数并进行病理学检查。结果cAP各治疗组大鼠前列腺指数小于模型对照组（P〈0．05），综合治疗组前列腺指数小于药物治疗组及运动治疗组（P〈0．05）。在治疗过程的4～22d，CAP模型对照组大鼠前列腺组织可见明显的慢性炎症病理学改变；运动治疗组、药物治疗组及综合治疗组大鼠前列腺慢性炎症改变均有不同程度减轻，其中，综合治疗组缓解程度较明显。结论游泳运动有利于前列腺组织炎性病理学损害的缓解，能够辅助大鼠cAP的治疗，与药物并用综合治疗大鼠CAP的病理学改变更加明显。Objective To investigate the pathological change and influence of the comprehensive treatment of swimming exercise and medicine for chronic abacterial prostatitis （CAP） in rats. Methods A total of 60 healthy adult male SD rats were randomly divided into the normal control group（n= 12） ,CAP model control group（n= 12）, exercise treatment group（n= 12）, medicine treatment group（n= 12）and exercise and medicine comprehensive treatment group（n=12）. The CAP rat model was established by Xiaozhiling injection. The medicine treatment group and comprehensive treatment group were given the corresponding medicine gavage treatment; the exercise treatment group and comprehensive treatment group were treated by taking exercise once daily,6 d per week, for 3 continuous weeks; the normal control group, CAP model control group and exercise treatment group were lavaged by sterile normal saline. The rat prostate in each group was taken on 4,8,11,14,18,22 d respectively, calculating the prostate index and taking the pathological examination. Results The rat prostate index in each CAP treatment group was less than that in the model control group （P〈0.05） ,the rat prostate index in comprehensive treatment group was less than that in the medicine treatment group and exercise treatment group （P〈0.05）. On 4-22 d during the treatment process,the prostate tissue in the CAP model control group showed obvious chronic inflammatory pathological changes; the change of prostate chronic inflammation in the exercise treatment group,medicine treatment group and comprehensive treatment group were relieved in different degree,among them, the comprehensive treatment group was relieved more obviously. Conclusion Swimming exercise is beneficial to the relief of inflammatory pathological damage in prostate tissue,and can help the treatment of CAP in rats,and the pathological change of its combining with medicine to treat the CAP is more obvious.

关 键 词：游泳 运动疗法 慢性病 前列腺 病理学 大鼠 sprague—dawley 

分 类 号：R697.33[医药卫生—泌尿科学]