复合七氟醚经鼻滴入舒芬太尼在婴儿肛周脓肿挂线术的适宜剂量  

Suitable dose of sufentanil by nasal instillation for infants with perianorectal abscess undergoing seton operation when combining with sevoflurane

作　　者：侯明时 

机构地区：[1]山东省临沂市妇女儿童医院麻醉科,276000

出　　处：《重庆医学》2016年第13期1787-1788,1792,共3页Chongqing medicine

摘　　要：目的探讨复合七氟醚经鼻滴入舒芬太尼在婴儿肛周脓肿挂线术的适宜剂量。方法选择择期拟在全身麻醉下行肛周脓肿挂线术的婴儿90例，ASA分级Ⅰ级，性别不限，年龄30～90d，体质量3．5～6．5kg，将婴儿随机分为3组（n=30）：舒芬太尼0．4μg／kg（S1组）、0．6μg／kg（S2组）、0．8μg／kg（S3组）。6％七氟醚麻醉诱导，意识消失后，调至4．5％，将舒芬太尼稀释至0．4mL，分别滴入鼻腔内，6min后开始手术。记录术中婴儿体动反应、心血管反应、呼吸暂停、苏醒时间、醒后哭闹例数。结果3组婴儿体动反应比较，差异无统计学意义（P〉0．05），与S1组比较，S2组和S3组术中心血管反应、醒后哭闹减少（P〈0．05），苏醒时间延长（P〈0．05）；S2组和S3组术中心血管反应、醒后哭闹比较，差异无统计学意义（P〉0．05），与S2组比较，S3组苏醒时间延长（P〈0．05）；与S3组比较，S1组和S2组呼吸暂停减少（P〈0．05），S1组和S2组呼吸暂停比较，差异无统计学意义（P〉0．05）。结论吸入4．5％七氟醚时经鼻滴入0．6μg／kg舒芬太尼用于30～90d婴儿行肛周脓肿挂线术效果好。Objective To determine the suitable dose of sufentanil by nasal instillation for infants with perianoreetal abscess undergoing seton operation when combining with sevoflurane. Methods Ninety infants, ASA grade Ⅰ , sex unlimited, aged 30-90 d old,weighed 3.5--6.5 kg, undergoing elective seton operation under general anesthesia, were randomly divided into 3 groups （n=30） ：sufentanil 0.4μg/kg（group S1 ） ,0.6μg/kg（group S2 ） and 0.8μg/kg（group S3 ）. 6% sevoflurane was inhaled for induction anesthesia, and then was maintained at 4.5 % after loss of consciousness,sufentanil was diluted to 0. 4 mL and instilled into the nasal cavity. After 6 min, the operation was begun. The introperative body moving responses, cardiovascular responses, apena, recovery time and crying were recorded. Results There was no statistically significant difference in the body movement responses among the three groups（P〉0.05）. Compared with the group S1, the cardiovascular responses and crying were significantly reduced in the group S2 and S3 （P〈0.05）, the recovery time was prolonged（P〈0.05）, the cardiovascular responses and crying had no statistical difference between the group S2 and S3 （P〉0.05）, compared with the group S2, the recovery time in the group S3 was prolonged （P〈0.05） ;compared with the group S3 ,the times of apena in group S1 and S2 were significantly reduced,and apena had no statistical difference between group S1 and S2 （P〉0.05）. Conclusion When inhaling 4.5 % sevoflurane 0.6μg/kg sufentanil by nasal instillation has better effect in 30-90 d old infants with perianorectal abscess seton operation.

关 键 词：投药 鼻内 舒芬太尼 七氟醚 肛周脓肿 

分 类 号：R726.1[医药卫生—儿科]