维生素D_3、钙、锌联合应用对婴幼儿佝偻病疗效研究  

Efficacy of the combination of VitD_3,Ca,and Zn for infantile rickets

作　　者：林晓燕[1] 张龙[1] 曾璐[1] 

机构地区：[1]河北北方学院附属第二医院儿科,河北张家口075100

出　　处：《海南医学院学报》2016年第12期1286-1288,共3页Journal of Hainan Medical University

基　　金：河北省科技进步获奖项目(2013JB2038-04)~~

摘　　要：目的：探讨维生素D（VitD）、钙（Ca）、锌（Zn）联合应用于婴幼儿佝偻病的临床疗效。方法：选取70例佝偻病患儿作为研究对象,随机分为研究组与对照组;对照组第一个月给予VitD3注射液30万IU肌肉注射,1次/月,第二个月改口服伊可新1粒/次,1次/d,迪巧1袋/次,1次/d,研究组在对照组基础上同时口服葡萄糖酸锌口服液10～20mL/d,两组疗程均为3个月;采集治疗前后外周血,采用全自动生化分析仪测定Ca、磷（P）、Zn、碱性磷酸酶（BALP）,ELISA法测定25-羟维生素D3[25-（OH）D3],单光子吸收计测定桡骨、尺骨骨密度,并进行疗效判定。结果：治疗后两组Zn、Ca、P、25-（OH）D3均较治疗前升高,BALP较治疗前降低,差异有统计学意义（P〈0.05）,研究组各生化指标改善优于对照组,差异有统计学意义（P〈0.05）;治疗后两组桡骨、尺骨骨密度高于治疗前,差异有统计学意义（P〈0.05）;研究组增高优于对照组,差异有统计学意义（P〈0.05）;研究组总有效率为94.3%,对照组为71.4%,差异有统计学意义（P〈0.05）。结论：VitD3、Ca、Zn联合用药可有效均衡佝偻病婴幼儿微量元素水平,提高骨密度,促进骨形成,疗效显著。Objective：To explore the clinical efficacy of the combination of VitD3,Ca,and Zn for infantile rickets.Methods：A total of 70 infants with rickets who were admitted in our hospital were included in the study and randomized into the study group and the control group.The patients in the control group were given VitD3 injection,300 000 IU,IM,1time/month for the first month,and then were given VitAD,1granule/time,1time/d,and D-Cal,1bag/time,1time/d,for the second month.On this basis,the patients in the study group were given zinc gluconate oral liquid,10～20mL/d.Three-month treatment was regarded as one course.The peripheral blood before and after treatment was collected.The full automatic biochemical analyzer was used to detect Ca,P,Zn,and BALP.ELISA was used to detect 25-（OH）D3.The single photon absorptionmeter was used to determine the bone mineral density of radius and ulna.The efficacy was estimated.Results：After treatment,Zn,Ca,P,and 25-（OH）D3in the two groups were significantly elevated,but BALP was significantly reduced when compared with before treatment（P〈0.05）.The improvement of various biochemical indicators in the study group was significantly superior to that in the control group（P〈0.05）.After treatment,the bone mineral density of radius and ulna in the two groups was significantly elevated when compared with before treatment（P〈0.05）.The elevated degree of bone mineral density in the study group was significantly superior to that in the control group（P〈0.05）.The total effective rate in the study group（94.3%）was significantly higher than that in the control group（71.4%）（P〈0.05）.Conclusions：The combination of VitD3,Ca,and Zn in the treatment of infantile rickets can balance the microelement level,synergize to promote the bone formation,and enhance the bone mineral density,with a safe and reliable efficacy;therefore,it could be widely recommended in the clinic.

关 键 词：维生素D3 钙 锌 婴幼儿 佝偻病 

分 类 号：R723.2[医药卫生—儿科]