RDW用于急性冠脉综合征冠脉病变严重程度评估的价值及其与血清指标的相关性  

Value of RDW in assessing severity of acute coronary syndrome and its correlation with serum indexes

作　　者：陈国栋[1] 

机构地区：[1]广东省东莞市人民医院心血管内科,广东东莞523500

出　　处：《海南医学院学报》2016年第12期1315-1317,1321,共4页Journal of Hainan Medical University

基　　金：2014年东莞市医疗卫生类科研一般项目(201410515000083)~~

摘　　要：目的:研究RDW用于急性冠脉综合征冠脉病变严重程度评估的价值及其与血清指标的相关性。方法:选择在广东省东莞市人民医院心内科确诊为急性冠脉综合征(ACS)的80例患者以及同期在该院体检中心体检的健康者80例进行研究,采集血清后测定RDW水平以及血清中炎性因子、心肌缺血分子、内皮保护分子的含量。结果:ACS患者的RDW显著高于健康者,NSTEMI患者、STEMI患者的RDW高于UAP患者,STEMI患者的RDW高于NSTEMI患者(均P<0.05);RDW水平越高,血清IL-37、CTRP9、Ghrelin、AMPK、AdipoR1、eNOS、NO含量越低,呈Q1>Q2>Q3>Q4的趋势(P<0.05);血清sTWEAK、sCD40L、CCR7、CCL21、CK-MB、cTnT、IMA、GDF-15、ox-LDL、LOX-1含量越高,呈Q1<Q2<Q3<Q4的趋势(P<0.05)。结论:RDW能够评估急性冠脉综合征的病情严重程度并且与机体的炎症反应程度、心肌缺血程度、内皮损伤程度相关。Objective：To study the value of RDW in assessing the severity of acute coronary syndrome and its correlation with serum indexes.Methods：A total of 80 cases diagnosed as acute coronary syndrome（ACS）in Department of Cardiology of our hospital as well as 80 healthy subjects receiving physical examination in Physical Examination Center of our hospital were selected for study.Serum was collected to detect RDW levels as well as the contents of inflammatory factors,myocardial ischemia molecules and endothelial protection molecules in serum.Results：RDW of ACS patients was significantly higher than that of healthy subjects,RDW of NSTEMI patients and STEMI patients were higher than that of UAP patients,and RDW of STEMI patients was higher than that of NSTEMI patients;the higher the RDW levels,the lower the serum IL-37,CTRP9,Ghrelin,AMPK,AdipoR1,eNOS and NO contents,showing the trend of Q1Q2Q3Q4;the higher the serum sTWEAK,sCD40 L,CCR7,CCL21,CK-MB,cTnT,IMA,GDF-15,ox-LDL and LOX-1contents,showing the trend of Q1Q2Q3Q4.Conclusions：RDW can assess the severity of acute coronary syndrome and is associated with the degree of inflammatory response,myocardial ischemia and endothelial protection.

关 键 词：急性冠脉综合征 红细胞体积分布宽度 炎性因子 心肌损伤 内皮保护 

分 类 号：R541.4[医药卫生—心血管疾病]