羟基磷灰石复合骨组织工程支架的研究进展  

Development of several biomimetic scaffold in bone tissue engineering

作　　者：许瑾[1] 吴晶晶[2,3] 王晓冬[1] 王秀梅[3] 韩倩倩[1] 

机构地区：[1]南京医科大学康达学院,江苏连云港222000 [2]中国地质大学(北京)工程与技术学院,北京100083 [3]清华大学材料科学与工程学院,北京100084

出　　处：《生物骨科材料与临床研究》2016年第2期63-66,共4页Orthopaedic Biomechanics Materials and Clinical Study

基　　金："十二五"国家科技支撑计划项目(项目编号:2012BAI17B02);国家自然科学基金资助项目(项目编号:21371106);国家自然科学基金资助项目(项目编号:31300814);江苏省高等学校大学生创新创业训练计划:201513980002Y

摘　　要：近年来,以生物活性陶瓷、聚合物等材料为基础复合而成的人工骨骼材料得到了广泛的研究并取得了巨大的进展。纳米羟基磷灰石(nano Hydroxyapatite,n HA)因其具有良好的生物相容性和生物活性,被大量应用于骨组织的移植与修复,但由于现有工艺制备的磷灰石本身力学性能不够完美,进而限制了其应用的广泛性,因此,制备综合性能优越的纳米羟基磷灰石/聚合物复合生物材料是当今骨组织工程中研究的热点。在此,就纳米羟基磷灰石与壳聚糖、胶原、聚乳酸等高分子材料复合而成的新型骨移植替代材料的合成方法、力学性能和生物相容性进行简单的介绍。Bioactive ceramic and polymer based artificial bone materials had been studied comprehensively and got considerable progress. Nano hydroxyapatite（n HA） is one of the most widely used material in bone repairing as its good biocompatibility and bioactivity. However, due to the poor mechanical properties, the clinical application of apatite by current process is limited. Therefore, the study of preparing superior comprehensive performance of nano hydroxyapatitepolymer composite biomaterials is a hotspot in the area of bone tissue engineering. The synthetic method, mechanical properties and biocompatibility of novel composite bone repairing materials through combining of nano hydroxyapatite andhigh molecular material such as chitosan, collagen, polylactic acid are introduced simply in the article.

关 键 词：纳米羟基磷灰石 人工骨骼 骨修复 复合物 

分 类 号：R318.08[医药卫生—生物医学工程] TB33[医药卫生—基础医学]