H型高血压患者血清Hcy、Cyst-C及UA水平变化及其在颈动脉粥样硬化中的预测价值  

H Type Hypertension:Changes of Serum Hcy, Cyst-C and UA Levels and Their Predictive Value in Carotid Atherosclerosis

作　　者：王骄[1] 郑向青 罗羽慧[1] 李晓丽[1] 梅霞[1] 

机构地区：[1]重庆市中山医院心血管内科,重庆400013

出　　处：《现代生物医学进展》2016年第12期2296-2299,共4页Progress in Modern Biomedicine

摘　　要：目的：探讨H型高血压患者血清同型半胱氨酸（Hcy）、尿酸（UA）及胱抑素C（Cyst-C）水平对颈动脉粥样硬化发生的预测价值。方法：本研究于2014年5月~2015年5月期间,选择我院收治确诊为H型高血压患者163例为研究对象,根据其颈动脉内膜中层厚度（c IMT）的不同分为c IMT正常组（51例）、c IMT增厚组（54例）和颈动脉斑块组（58例）。检测并比较三组间性别、年龄、血清Hcy、Cyst-C、UA、血糖（GLU）、血脂、血尿素氮（Bun）、血肌酐（Scr）水平,分析其与颈动脉c IMT的关系,并采用logistic回归分析颈动脉粥样硬化的影响因素。结果：三组间HDL-C、Hcy、Cyst-C、UA水平比较,差异均存在统计学意义（均P〈0.05）;c IMT与Hcy、Cyst-C、UA均呈现正相关关系（r=0.23,0.32,0.30;P〈0.05）,与HDL-C水平呈现负相关关系（r=-0.410,P〈0.05）;Logistic回归分析显示Hcy、Cyst-C、UA水平是颈动脉粥样硬化危险因素（OR=1.203,6.395,1.023;均P〈0.05）。结论：H型高血压患者血清Hcy、Cyst-C及UA水平均与c IMT正相关,是导致颈动脉粥样硬化的独立危险因素,可用于临床早期预测动脉粥样硬化发生与发展。Objective： To explore the predictive value of serum hyperhomocysteine（Hcy）, uric acid（UA） and cystatin C（Cyst-C）levels in the occurrence of carotid atherosclerosis in patients with H type hypertension. Methods： A total of 163 patients with H type hypertension, who were admitted to Chongqing Zhongshan Hospital from May 2014 to May 2015, were chosen as research subjects and divided into normal carotid intima-media thickness（c IMT） group（n=51）, thickened c IMT group（n=54） and carotid artery plaque group（n=58） according to the difference of c IMT. The gender, age, serum Hcy, Cyst-C, UA, blood glucose（GLU）, blood lipid, blood urea nitrogen（Bun） and serum creatinine（Scr） levels among the three groups are detected and compared, and their correlation with c IMT was analyzed. The influencing factors of carotid atherosclerosis were analyzed by logistic regression analysis. Results： There were significant differences in the HDL-C, Hcy, Cyst-C and UA levels among the three groups（P〈0.05）. c IMT was positively correlated with the serum Hcy, Cyst-C and UA（r=0.23, 0.32, 0.30; P〈0.05）, negatively correlated with HDL-C（r=-0.410, P〈0.05）. Logistic regression analysis showed that the levels of Hcy, Cyst-C and UA were the risk factors of carotid atherosclerosis（OR=1.203, 6.395, 1.023; P〈0.05）.Conclusion： Serum Hcy, Cyst-C and UA levels are positively correlated with c IMT in the patients with H type hypertension. They are the independent risk factors leading to carotid atherosclerosis,which can be used to predict the occurrence and development of atherosclerosis in the early stage in clinic.

关 键 词：同型半胱氨酸 尿酸 胱抑素C 高血压 动脉粥样硬化 

分 类 号：R544.1[医药卫生—心血管疾病] R543.5[医药卫生—内科学]