脂肪干细胞的研究进展  

Research Progress of Adipose-derived Stem Cells

作　　者：孙惠君[1] 李博[1] 陈书强[1] 芦洁[1] 王晓红[1] 

机构地区：[1]第四军医大学唐都医院妇产科生殖医学中心,陕西西安710038

出　　处：《现代生物医学进展》2016年第12期2380-2383,共4页Progress in Modern Biomedicine

基　　金：陕西省科技统筹创新工程计划资源主导型产业关键技术(链)项目资助(2013KTCL03-07);国家自然科学基金项目(81370710)

摘　　要：成体干细胞包括多能诱导干细胞、胚胎干细胞、脐带血干细胞、脂肪干细胞等,其中脂肪干细胞因其取材方便,无伦理限制,且能诱导成多胚层细胞而成为最有应用前景的成体干细胞之一。脂肪干细胞可以诱导分化为脂肪细胞、骨细胞、软骨细胞、肌细胞和神经元,在特定的条件下,可以构建皮肤,骨和软骨组织工程,是多种组织工程的理想种子细胞,有非常重要的研究和应用价值。本文综述了ADSC的分离培养、诱导分化,并着重对脂肪干细胞在组织工程临床应用方面的最新发展进行了阐述,以期为深入研究脂肪干细胞提供理论基础。Adipose-derived stem cells（ADSCs） are one of the most promising stem cell types, including induced pluripotent stem cells（i PSCs）, embryonic stem cells（ESCs） and umbilical cord blood stem cells, etc. Unlike ESCs and i PSCs, ADSCs do not only have such limitations and are not only easily obtained but also no ethical restrictions. ADSCs can differentiate into adipocytes, osteoblasts,chondrocytes, myocytes and neurons under specific differentiation conditions, and these kinds of differentiation potential of ADSCs could be applied in regenerative medicine e.g. skin reconstruction,bone and cartilage formation, etc. ADSCs is the ideal seed cells for tissue engineering. In this review, the current status of ADSC isolation, differentiation and their therapeutic applications are discussed. Hoping to provide a theoretical basis for further research adipose stem cells.

关 键 词：脂肪干细胞 分离培养 诱导分化 组织工程 临床应用前景 

分 类 号：Q813[生物学—生物工程] R318[医药卫生—生物医学工程]