布地奈德雾化吸入对肺炎支原体肺炎患儿临床症状、肺功能及体液免疫功能的影响  

The Effect of Budesonide Aerosol Inhalation on Clinical Symptoms,Pulmonary Function and Humoral Immune in Children with Mycoplasma Pneumoniae Pneumonia

作　　者：蔡金龙[1] 田执梁[1] 张驰[1] 张娟[1] 曲书强[1] 

机构地区：[1]哈尔滨医科大学附属第二医院,黑龙江哈尔滨150001

出　　处：《儿科药学杂志》2016年第5期15-17,共3页Journal of Pediatric Pharmacy

摘　　要：目的：探讨布地奈德雾化吸入对肺炎支原体肺炎（MPP）患儿临床症状、肺功能及体液免疫功能的影响。方法：选取2014年9月至2015年1月于我院住院的MPP患儿60例,随机分为对照组和观察组各30例。对照组给予阿奇霉素常规治疗（10 mg/kg,1次/天,用3 d停4 d）,观察组在对照组治疗基础上加用布地奈德混悬液雾化吸入（每次2 m L,每天2次,每次间隔4~6 h）。测定患儿治疗前和治疗2周后的血清免疫球蛋白（Ig G、Ig A、Ig M）水平（散射比浊法）、肺功能（肺功能仪）,观察患儿临床症状及肺部体征改善情况。结果：观察组患儿治疗前和治疗2周后的血清免疫球蛋白（Ig G、Ig A、Ig M）水平差异无统计学意义（P〉0.05）;咳嗽消失时间、干湿啰音消失时间短于对照组（P〈0.05）;治疗2周后肺功能指标肺活量（FVC）、FEF75改善率高于对照组（P〈0.05）。结论：布地奈德雾化吸入对MPP患儿的体液免疫功能无影响,是MPP的有效辅助治疗方法之一,值得临床进一步观察研究。Objective： To explore the effect of budesonide aerosol inhalation on clinical symptoms,pulmonary function and humoral immune in children with Mycoplasma pneumonia pneumonia. Methods： Sixty cases of children with Mycoplasma pneumoniae pneumonia were selected from September 2014 to January 2015. All children were randomly divided into control group（ 30 cases） and experimental group（ 30 cases）. The control group was given conventional treatment. The experimental group was given both the conventional treatment and atomization inhalation of budesonide（ 2 m L one time,2 times every day）. Scattering turbidimetric method was used to measure the level of blood immunoglobulin（ Ig G,Ig A,Ig M）. And at the same time the lung function of the children were tested and the clinical symptoms and signs of children were observed. Results：（ 1） The levels of immunoglobulin（ Ig A,Ig G,Ig M） before treatment in the experimental group were not different with those after two weeks of treatment（ P 0. 05）.（ 2） Duration of cough and lung signs turnaround time in the experimental group were significantly shorter than those in the control group,the differences were statistically significant（ P0.05）.（ 3） After two weeks＇ treatment,lung function of the experimental group such as vital capacity（ FVC） and improvement rate of FEF75 were significantly higher than the control group,the differences were statistically significant（ P 0. 05）.Conclusion： Atomization inhalation of budesonide is a kind of auxiliary treatment method in mycoplasma pneumonia pneumonia and it has no effect on humoral immunity of children.

关 键 词：肺炎支原体 布地奈德 肺功能 免疫球蛋白 

分 类 号：R725.6[医药卫生—儿科]