孕期优生检查孕妇乙型肝炎五项结果报告分析  

Report analysis of the five results of hepatitis B in pregnant women of pregnancy prenatal examination

作　　者：唐海燕 

机构地区：[1]广东省云浮市云安区妇幼保健和计划生育服务中心,广东云浮527300

出　　处：《中国当代医药》2016年第10期165-167,170,共4页China Modern Medicine

摘　　要：目的探讨孕妇乙型肝炎流行情况与各年龄组乙型肝炎表面抗体含量,为合理接种乙型肝炎疫苗提供参考依据。方法选取2013年1月~2015年7月本院的2276例孕妇作为研究对象,采用时间分辨荧光免疫分析法（TRFIR）进行乙型肝炎五项定量检测。结果 2276例孕妇中,312例为乙型肝炎阳性,感染率为13.7%,其中45.5%显示HBs Ag、HBe Ab、HBc Ab为阳性,39.4%显示HBs Ag、HBe Ag、HBc Ab为阳性,8.9%显示HBs Ag、HBc Ab为阳性,1.9%显示HBs Ag、HBe Ag为阳性,0.9%显示HBs Ag为阳性,1.9%显示HBs Ag、HBe Ab为阳性,1.3%显示HBs Ag、HBs Ab为阳性。20~25岁组的HBs Ab含量显著低于26~30岁组与31~40岁组,差异有统计学意义（P〈0.05）。26~30岁组的HBs Ab含量与31~40岁组比较,差异无统计学意义（P〉0.05）。2276例孕妇中,1182例HBs Ab阳性,阳性率为51.9%。26~30岁组的HBs Ab阳性率与高免疫应答率显著高于20~25岁组与31~40岁组,差异有统计学意义（P〈0.05）。20~25岁组的低免疫应答率显著高于26~30岁组与31~40岁组,差异有统计学意义（P〈0.05）。结论对于已感染与易感染HBV的孕妇,乙型肝炎定量检测可反映机体乙型肝炎感染动态免疫情况,有利于控制HBV感染,阻断母婴传播,实现优生优育。Objective To explore the prevalence situation of hepatitis B in pregnant women and the content of hepatitis B surface antibody in each age group,and to provide reference data for the reasonable inoculation of hepatitis B vaccine. Methods 2276 pregnant women in our hospital from January 2013 to July 2015 were selected as the research group,five quantification of hepatitis B was detected by time resolved fluorescence immunoassay（TRFIR）. Results In2276 cases of pregnant women,312 cases of hepatitis B were positive,the infection rate was 13.7%.45.5% patients showed that the HBs Ag,HBe Ab,HBc Ab were positive,39.4% patients showed that the HBs Ag,HBe Ag,HBc Ab were positive,8.9% patients showed that the HBc Ab,HBs Ag were positive,1.9% patients showed that the HBe Ag,HBs Ag were positive,0.9% patients showed that the HBs Ag was positive,1.9% patients showed that the HBe Ab,HBs Ag was positive,1.3% patients showed that the HBs Ab,HBs Ag was positive.The content of HBs Ag in the 20-25 years old group was lower than that in 26-30 years old group and 31-40 years old group,with significant difference（P〈0.05）.There was no significant difference in the content of HBs Ag between 26-30 years old group and 31-40 years old group（P〉0.05）.In2276 pregnant women,1182 cases of hepatitis B surface antibody were positive,and the positive rate was 51.9%.The positive rate of HBs Ab and high immune response rate in 26-30 years old group was higher than that in 20-25 years old group and 31-40 years old group,with significant difference（P〈0.05）.The low immune response rate in the 20-25 years old group was higher than that in 26-30 years old group and 31-40 years old group,with significant difference（P〈0.05）. Conclusion For pregnant women infected with HBV and susceptible to HBV infection,the quantitative detection of hepatitis B can reflect to the dynamic immune situation of hepatitis B infection,which is conducive to the control of HBV infection and prevention of mother to child transmission for eugenics.

关 键 词：乙型肝炎五项定量 乙型肝炎表面抗体含量 时间分辨荧光免疫分析法 孕期优生检查 

分 类 号：R715.2[医药卫生—妇产科学]