两面针根和茎抗胃炎、保护胃黏膜和改善胃肠运动功能的作用比较研究  

Comparative Study on Effects of Anti-Gastritis,Gastric Mucosal Protection and Gastrointestinal Movement Promotion of Root and Stem of Zanthoxylum nitidum

作　　者：秦泽慧[1,2,3] 陈炜璇[1,4] 李茹柳[2] 韩正洲[1,4] 仰铁锤 詹若挺[1] 陈蔚文[1,2] 

机构地区：[1]广州中医药大学中药资源科学与工程研究中心/(省部共建)岭南中药资源教育部重点实验室,广东广州510006 [2]广州中医药大学脾胃研究所,广东广州510405 [3]厦门医学高等专科学校,福建厦门361008 [4]华润三九医药股份有限公司,广东深圳518110

出　　处：《中药材》2016年第1期164-169,共6页Journal of Chinese Medicinal Materials

基　　金：广东省教育部产学研结合项目(2009B090300202);深圳市生物产业发展专项资金项目(ZYC201006130324A)

摘　　要：目的:比较两面针根和茎抗胃炎、保护胃黏膜和改善胃肠运动功能的药效作用,为两面针以茎入药,扩大药用部位提供实验依据。方法:采用碘代乙酰胺致大鼠慢性浅表性胃炎观察比较两面针根、茎的抗胃炎作用,采用大鼠应激性胃溃疡模型、吲哚美辛致大鼠胃溃疡和大鼠幽门结扎模型观察比较两面针根、茎的胃黏膜保护作用,采用小鼠胃排空和小肠推进实验观察比较两面针根、茎改善胃肠运动功能的作用。结果:两面针根、茎均有不同程度改善大鼠慢性浅表性胃炎胃黏膜组织炎症、应激性胃溃疡及吲哚美致大鼠胃溃疡的溃疡指数和胃液分析指标,同时在促进胃肠蠕动方面也表现出有较好的药效。结论:两面针茎在抗胃炎、保护胃黏膜和改善胃肠运动功能方面的药效作用与两面针根相近。Objective： To provide the experimental evidence for expansion of medicinal parts of Zanthoxylum nitidum by comparing the effects of anti-gastritis,gastric mucosal protection and gastrointestinal movement promotion of its root and stem. Methods： The pharmacological effects between root and stem of Zanthoxylum nitidum were compared by observing the anti-gastritis effect on rats with chronic superficial gastritis induced by iodoacetamide,evaluating the gastric mucosal protective effect on rats＇ gastric ulcer induced by stress,indometacin and pylorus ligation test,and investigating gastrointestinal movement promotion effect on mice gastric evacuation and intestinal propelling. Results： Both root and stem of Zanthoxylum nitidum showed effects of relieving the inflammation symptoms of rats＇ gastric mucosa induced by iodoacetamide,gastric ulcer respectively induced by stress,and presenting a strong inhibition of free acid and pepsin activity in gastric juice. Furthermore stem parts of Zanthoxylum nitidum in promoting gastrointestinal motility even showed better efficacy than root. Conclusion： Stem of Zanthoxylum nitidum has similar effects of anti-gastritis,gastric mucosal protection and gastrointestinal movement promotion with root of Zanthoxylum nitidum.

关 键 词：两面针 药用部位 抗胃炎 保护胃黏膜 胃肠运动功能 

分 类 号：R285.5[医药卫生—中药学]