Association Analysis of Proteasome Subunits and Transporter Associated with Antigen Processing on Chinese Patients with Parkinson＇s Disease  

作　　者：Ming-Shu Mo Wei Huang Cong-Cong Sun Li-Min Zhang Luan Cen You-Sheng Xiao Guo-Fei Li Xin-Ling Yang Shao-Gang Qu Ping-Yi Xu 

机构地区：[1]Department of Neurology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510080, China [2]Department of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China [3]Department of Neui01ogy, Qilu Affiliated Hospital of Shandong University, Jinanl Shah(long 250001China [4]Department of Neurology, Huaihe Hospital, Henan University, Kaifeng, Henan 475080, China [5]Department of Neurology, The Third Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 393100, China [6]Department of Immunology, School of Basic Medical sciences, Southern Medical University, Guangzhoul Guangdong 510515, China [7]Department of Neurology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, China

出　　处：《Chinese Medical Journal》2016年第9期1053-1058,共6页中华医学杂志（英文版）

基　　金：Supplementary information is linked to the online version of the paper on the Chinese Medical Journal website.This work was supported by research grants from the National High Technology Research and Development Program of China （grant No. 2007AA02Z460）, the State Key Development Program for Basic Research of China （grant No. 2011CB510000）, the National Natural Science Foundation of China （grant No. 81271428, 81471292, U1503222, and 81430021） and the key point Science Foundation of Guangdong of China （No. 2015A030311021）, a grant supported by technology project of Guangzhou （No. 20151260） and a grant supported by assisting research project of science and technology for Xinjiang （No. 201591160）.

摘　　要：Background： Proteasome subunits （PSMB） and transporter associated with antigen processing （TAP） loci are located in the human leukocyte antigen （HLA） Class I1 region play important roles in immune response and protein degradation in neurodegenerative diseases. This study aimed to explore the association between single nucleotide polymorphisms （SNPs） of PSMB and TAP and Parkinson＇s disease （PD）. Methods： A case-control study was conducted by genotyping SNPs in PSMB8, PSMBg, TAP1, and TAP2 genes in the Chinese population. Subjects included 542 sporadic patients with PD and 674 healthy controls. Nine identified SNPs in PSMB8, PSMBg, TAP1, and TAP2 were genotyped through SNaPshot testing. Results： The stratified analysis ofrs 17587 was specially performed on gender. Data revealed that female patients carry a higher frequency of rsl7587-G/G versus （A/A ＋ G/A） compared with controls. But there was no significant difference with respect to the genotypic frequencies of the SNPs in PSMB8, TAP1, and TAP2 loci in PD patients. Conclusion： Chinese females carrying the rs 17587-G/G genotype in PSMB9 may increase a higher risk for PD, but no linkage was found between other SNPs in HLA Class II region and PD.Background： Proteasome subunits （PSMB） and transporter associated with antigen processing （TAP） loci are located in the human leukocyte antigen （HLA） Class I1 region play important roles in immune response and protein degradation in neurodegenerative diseases. This study aimed to explore the association between single nucleotide polymorphisms （SNPs） of PSMB and TAP and Parkinson＇s disease （PD）. Methods： A case-control study was conducted by genotyping SNPs in PSMB8, PSMBg, TAP1, and TAP2 genes in the Chinese population. Subjects included 542 sporadic patients with PD and 674 healthy controls. Nine identified SNPs in PSMB8, PSMBg, TAP1, and TAP2 were genotyped through SNaPshot testing. Results： The stratified analysis ofrs 17587 was specially performed on gender. Data revealed that female patients carry a higher frequency of rsl7587-G/G versus （A/A ＋ G/A） compared with controls. But there was no significant difference with respect to the genotypic frequencies of the SNPs in PSMB8, TAP1, and TAP2 loci in PD patients. Conclusion： Chinese females carrying the rs 17587-G/G genotype in PSMB9 may increase a higher risk for PD, but no linkage was found between other SNPs in HLA Class II region and PD.

关 键 词：Han Chinese Proteasome Subunit Beta Type Sporadic Parkinson＇s Disease TAP 

分 类 号：Q347[生物学—遗传学] Q426