离子通道在哮喘发病机制中作用的研究进展  

Research progress of ion channels in the mechanism of asthma

作　　者：蔡上逍 菅朝慧 顾豪[1] 何白慧 江一鸣[1,2] 

机构地区：[1]上海交通大学基础医学院,上海200025 [2]上海交通大学医学院附属仁济医院耳鼻咽喉科,上海200127

出　　处：《上海交通大学学报（医学版）》2016年第4期580-583,共4页Journal of Shanghai Jiao tong University:Medical Science

基　　金：国家自然科学基金(91413122)~~

摘　　要：近年来,支气管哮喘(简称哮喘)的全球发病率呈上升趋势,因此,哮喘发病机制及治疗靶点的相关研究也越来越深入和广泛。目前发现与哮喘相关的离子通道包括钙离子通道、钾离子通道、上皮钠离子通道、酸敏感离子通道及瞬时感受器电位通道等。该文对离子通道在哮喘发病机制中作用的研究进展以及不同离子通道作为哮喘治疗靶点的应用前景进行综述。In recent years, the prevalence of bronchial asthma （asthma for short） is increasing globally. Thus, more thorough and broad studies on pathogenesis and therapeutic targets of asthma have been carried out. Identified ion channels that are associated with asthma include Ca2＋ channels, K ＋ channels, epithelial sodium channels, acid-sensing ion channels, and transient receptor potential channels, etc. In this review we present research progresses of pathogenesis of asthma and the prospect of applying different ion channels as therapeutic targets of asthma.

关 键 词：离子通道 支气管哮喘 支气管平滑肌痉挛 变态反应性气道炎症 

分 类 号：R562.25[医药卫生—呼吸系统]