甲巯咪唑治疗甲亢的临床效果  

The Clinical Effect of Methimazole in Treatment of Hyperthyroidism

作　　者：张秀坤[1] 孙巍[1] 于淼[1] 王哲[1] 孙琳[1] 徐明艳[1] 邹香妮 

机构地区：[1]黑龙江省医院南岗分院,黑龙江哈尔滨150001 [2]黑龙江省中医药大学附属第一医院,黑龙江哈尔滨150036

出　　处：《中国卫生标准管理》2016年第6期99-100,共2页China Health Standard Management

摘　　要：目的研究分析甲亢患者接受甲巯咪唑长期治疗的临床效果。方法根据2010年1月~2012年5月我院的60例甲亢患者进行研究分析,为其提供长期甲巯咪唑治疗,采取口服的给药方式,患者症状改善后,维持长期使用,对患者进行2年随访,分析患者的甲状腺功能改善情况和治疗效果、不良反应等。结果 60例患者经治疗总有效率为91.67%,复发率为5.00%,患者的甲状腺各项指标治疗前后比较差异有统计学意义（P〈0.01）;60例患者中,有7例患者粒细胞减少,2例药物性皮疹,对症处理后均缓解,未见其他明显不良反应。结论甲巯咪唑长期服用能够对甲亢患者的甲状腺功能起到较好的改善作用,临床不良反应少。Objective To study the clinical effect of hyperthyroidism patients receiving long-term treatment with methimazole. Methods According to the 60 cases of hyperthyroidism from January 2010 to may 2012 in our hospital to conduct research and analysis. To provide long-term treatment with methimazole,take oral administration and the improvement of symptoms,maintain long-term use,2 years of follow-up. Analysis of thyroid function in patients with improved conditions and treatment effect,adverse reactions and so on. Results 60 patients after treatment,total effective rate was 91.67%,the recurrence rate was 5.00%. Before and after the treatment,patients with thyroid indicators had significant difference（P〈0.01）. 60 patients,7 cases patients with neutropenia,2 cases of drug rash,after symptomatic treatment were relieved. No other obvious adverse reactions. Conclusion The longterm use of methimazole of thyroid function in patients with hyperthyroidism can play a better effect, less clinical adverse reaction.

关 键 词：长期治疗 甲巯咪唑 甲亢 

分 类 号：R581.1[医药卫生—内分泌]