幽门螺杆菌感染与急性心肌梗死患者血清炎症反应的关系  

Correlation of Helicobacter Pylori Infection with Serum Inflammation Reaction in Patients with Acute Myocardial Infarction

作　　者：徐琳萍[1] 李广运[1] 陈旭杰[1] 连延华 张晓乐[1] 王文斌[2] 

机构地区：[1]南阳市第二人民医院心内科,河南南阳473000 [2]郑州大学第一附属医院胃肠科,河南郑州450007

出　　处：《现代生物医学进展》2016年第11期2127-2129,共3页Progress in Modern Biomedicine

基　　金：河南省医学科技攻关基金项目(200803082)

摘　　要：目的:探讨幽门螺杆菌(Hp)感染与急性心肌梗死(AMI)患者血清炎症反应的关系,为临床防治AMI提供参考。方法:选取2013年4月-2014年11月我院收治的74例AMI患者作为研究组,另选取同期在我院进行体检的74例健康人作为对照组。采用酶联免疫法检测和比较两组患者Hp免疫球蛋白G(Immunoglobulin G,IgG)浓度及血清IL-6、IL-8、IL-18、TNF-α和hs-CRP水平,分析Hp IgG阳性与血清炎症因子水平的相关性。结果:研究组患者的Hp IgG浓度为(60.92±45.15)KU/L,相比于对照组的(32.36±24.08)KU/L明显偏高(P<0.05),且其阳性率为72.97%,明显高于对照组的51.35%(P<0.05);Hp阳性患者IL-6、IL-8、IL-18、TNF-α、hs-CRP明显高于Hp阴性患者的(P<0.05)。Pearson相关分析显示Hp IgG浓度与血清IL-6、IL-8、IL-18、TNF-α、hs-CRP水平均呈显著正相关,相关系数分别为0.735、0.644、0.798、0.674、0.616(P<0.05)。结论:Hp感染与AMI患者血清炎症反应之间存在着密切的关系。Objective： To investigate the correlation of Helicobacter pylori（Hp） infection with serum inflammation reaction in patients with acute myocardial infarction（AMI） so as to provide the reference for the prevention and treatment of AMI.Methods： 74 patients with AMI treated in our hospital from April 2013 to November 2014 were selected as the study group,meanwhile 74 healthy people were selected as the control group.The concentration of Hp Immunoglobulin G（IgG） of two groups were detected by enzyme-linked immunosorbent assay（ELISA） method,and the serum IL-6,IL-8,IL-18,TNF-α and hs-CRP were also detected,then the correlation of Hp IgG positive with serum inflammation factors were analyzed.Results： The concentration of Hp IgG was（60.92 ±45.15） KU/L in study group,which was significantly higher than（32.36±24.08） KU/L of the control group（P〈0.05）,and the Hp positive rate of study group was 72.97%,which was higher than 51.35% in the control group（P〈0.05）.The serum IL-6,IL-8,IL-18,TNF-α and hs-CRP levels in Hp positive patients were significantly higher than those of the Hp negative patients（P〈0.05）.Hp IgG concentration was positively correlated with the serum IL-6,IL-8,IL-18,TNF-α and hs-CRP levels（r=0.735,0.644,0.798,0.674,0.616,P〈0.05）.Conclusion： Hp infection was closely correlated with the serum inflammation reaction in patients with AMI.

关 键 词：幽门螺杆菌感染 急性心肌梗死 血清炎症反应 

分 类 号：R542.22[医药卫生—心血管疾病]