ABHD2基因与慢性阻塞性肺疾病关系的研究进展  

Research Progress of the Relationship between ABHD2 Genes and Chronic Obstructive Pulmonary Disease

作　　者：赵婷婷[1] 强丽霞[1] 李香顺[1] 吕娜[1] 金寿德[1] 

机构地区：[1]哈尔滨医科大学附属第四医院呼吸内科,黑龙江哈尔滨150001

出　　处：《现代生物医学进展》2016年第11期2172-2174,共3页Progress in Modern Biomedicine

基　　金：黑龙江省留学归国科学基金项目(LC201024);黑龙江省高等教育学会"十二五"教育科学研究规划课题(14G066)

摘　　要：ABHD2是在人体内表达的一种水解酶蛋白(/hydrolase protein),尽管底物尚不清楚,但其与慢性阻塞性肺疾病(COPD)的发生具有密切的相关性。ABHD2基因在肺部主要表达在肺泡II型细胞和肺支气管的非管型平滑肌细胞,参与调节肺泡表面活性物质的合成和分泌。相关研究显示ABHD2基因敲除小鼠可自发形成肺气肿表型。此外,人ABHD2基因的rs12442260多态性可增加COPD的发病风险。因此,ABHD2基因在慢性阻塞性肺疾病的发生发展过程中起着重要的作用。本文主要就ABHD2基因表达与COPD、肺气肿等疾病的相关性进行综述。ABHD2 is a hydrolase protein（ /hydrolase protein） that expresses in the human body,which is closely related with chronic obstructive pulmonary disease though the substrate is not clear.Abhd2 gene in lung mainly expresses in alveolar type II cells and lung bronchial tube smooth muscle cells,participates in the regulation of pulmonary surfactant synthesis and secretion.Related studies show that the Abhd2 gene knockout mice can spontaneously form the emphysema phenotype and the rs12442260 polymorphism of ABHD2 gene can increase the risk of COPD.So it is suggested that ABHD2 gene plays an important role in the development of chronic obstructive pulmonary disease.

关 键 词：ABHD2 慢性阻塞性肺疾病 肺气肿 

分 类 号：R563.3[医药卫生—呼吸系统]