胎盘生长因子抗体对大鼠子宫内膜异位症模型的治疗作用  

Effect of anti-placenta growth factor antibody on endometriosis in rats

作　　者：曾昭智[1] 张锦红[1] 陆少君[1] 

机构地区：[1]广东药科大学实验动物中心,广东广州510006

出　　处：《广东药学院学报》2016年第2期228-230,共3页Academic Journal of Guangdong College of Pharmacy

基　　金：广东省医学科研基金(B2013191)

摘　　要：目的探讨胎盘生长因子抗体(anti-PLGF)对大鼠子宫内膜异位症模型的治疗作用。方法自体移植法建立大鼠子宫内膜异位症模型,分别观察anti-PLGF对大鼠子宫内膜异位症模型异位子宫内膜形态结构、腹腔液血管内皮生长因子和白细胞介素-8的影响。结果 anti-PLGF 1 mg/kg剂量组能明显抑制模型大鼠腹腔液中血管内皮生长因子水平,并能显著减小大鼠子宫内膜异位组织的体积,与模型组比较差异有统计学意义(P<0.05),而腹腔液中白细胞介素-8水平无明显变化。结论 anti-PLGF通过抑制异位内膜的血管形成,从而有效抑制异位内膜的生长。Objective To explore the effect of anti-placenta growth factor（ PLGF） antibody on endometriosis in rats. Methods The endometriosis model was established by autologous transplantation of endometrial tissue in rats. The effect of anti-PLGF antibody on the production of peritoneal VEGF and IL-8 and endometrium morphosis in endometriosis rats were detected. Results Compared with the model group,treatment with anti-PLGF antibody（ 1 mg / kg） reduced the level of VEGF and the volume of endometriosis tissue in rats（ P〈0.05）. But the level of IL-8 did not show a significant difference in both groups. Conclusion Treatment with anti-PLGF antibody can inhibit the vasifaction and growth of ectopic endometrium in rats.

关 键 词：胎盘生长因子抗体 子宫内膜异位症 血管内皮生长因子 白细胞介素-8 

分 类 号：R711.71[医药卫生—妇产科学]