丙种球蛋白联合甲泼尼龙冲击治疗急性格林-巴利综合征的疗效观察  

Observation on Efficacy of Gamma Globulin Combined with Methylprednisolone Pulse Therapy in Treatment of Acute Guillain-Barre Syndrom

作　　者：段金平[1] 

机构地区：[1]河南省太康县人民医院神经内科,河南周口461400

出　　处：《中国医院用药评价与分析》2016年第4期458-460,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:研究丙种球蛋白联合甲泼尼龙冲击治疗急性格林巴-利综合征的疗效及安全性。方法:选择2009年7月—2015年2月河南省太康县人民医院就诊的120例急性格林巴-利综合症患者为研究对象,按照随机数字表法分为观察组和对照组,每组各60例,观察组患者行丙种球蛋白联合甲泼尼龙冲击治疗,对照组患者行单纯丙种球蛋白治疗,治疗4周后观察2组患者疗效和安全性。结果:观察组患者总有效率为91.67%(55/60),显著高于对照组的73.33%(44/60),差异有统计学意义(P<0.05)。2组患者治疗过程中均未发生严重不良反应。结论:丙种球蛋白联合甲泼尼龙冲击治疗的疗效显著优于单纯丙种球蛋白治疗时,且该联合疗法近期无严重不良反应。OBJECTIVE：To study the efficacy and safety of gamma globulin combined with methylprednisolone pulse therapy in treatment of acute Guillain-Barre Syndrom（GBS）.METHODS：120 cases of acute GBS admitted into Henan Taikang County People＇s Hospital from Jul.2009 to Feb.2015 were selected to be divided into observation group and control group via the random number table,with 60 cases in each.The observation group were treated with gamma globulin combined with methylprednisolone pulse therapy,while the control group received gamma globulin alone.After 4 weeks of treatment,the efficacy and safety of the treatment in two groups were observed.RESULTS：The total effective rate of the observation group was 91.67%（55 /60）,significantly higher than that of control group[73.33%（44 /60） ],with statistically significant difference（P〈 0.05）.There was no severe adverse reaction in two group of patients during treatment.CONCLUSIONS：The efficacy of gamma globulin combined with methylprednisolone pulse therapy is better than that of using gamma globulin treatment scheme alone,and the combined therapy is of no serious adverse reaction recently.

关 键 词：丙种球蛋白 甲泼尼龙 急性格林巴-利综合征 疗效 

分 类 号：R971[医药卫生—药品]