芪白平肺颗粒镇咳祛痰平喘作用的实验研究  

Antitussive, Expectorant and Antiasthmatic Effects of Qibaipingfei Granules

作　　者：孙晓萍[1,2] 李卓琼[1,2] 常秀娟[1,2] 李威[1,2] 周军[1,2] 王振中[1,2] 萧伟[1,2] 

机构地区：[1]江苏康缘药业股份有限公司,连云港222001 [2]中药制药过程新技术国家重点实验室,连云港222001

出　　处：《世界科学技术-中医药现代化》2016年第3期489-492,共4页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：科学技术部国家科技重大专项"重大新药创制"项目(2013ZX09402203):现代中药创新集群与数字制药技术平台;负责人:萧伟

摘　　要：目的 :考察芪白平肺颗粒(QBPF)的镇咳、祛痰和平喘作用。方法:采用氨水致小鼠咳嗽,利用小鼠气管酚红排泄法、豚鼠诱喘法评价药物的镇咳、祛痰和平喘作用。结果:芪白平肺颗粒高中低剂量组均能明显减少小鼠咳嗽次数,对延长咳嗽潜伏期也有一定的作用趋势。芪白平肺颗粒各剂量组均能明显增加酚红排出量,具有较好祛痰作用。芪白平肺颗粒各剂量组能明显延长豚鼠引喘潜伏期,高剂量可明显延长跌扑时间。结论:芪白平肺颗粒具有较好的止咳、化痰、平喘作用。This study was aimed to investigate the antitussive, expectorant and antiasthmatic effects of Qibaipingfei（QBPF） granules. Cough model was induced by ammonia. Asthma model was induced by histamine and acetylcholine in guinea pig. And the expectorant experiment was determined by phenol sulphonphthalein excretion in mice to evaluate the antitussive, expectorant and antiasthmatic effects of drug. Compared with the model group, the number of cough was significantly decreased in each dose of QBPF groups. And there was lower trend in latency of cough with no significant differences. The excretory amounts of phenol sulphonphthalein were increased by all doses of QBPF groups. The latency of asthma was extended in all doses of QBPF groups and fell time was increased by high dose of QBPF group. It was concluded that QBPF granules has significant antitussive, expectorant and antiasthmatic effect.

关 键 词：芪白平肺颗粒 镇咳 祛痰 平喘 

分 类 号：R283[医药卫生—中药学]