温湿化高流量鼻导管通气治疗极低出生体质量儿呼吸暂停的半随机对照研究  被引量:8

Quasi-randomized control trial of heated humidified high-flow nasal cannula in treatment of very low birth weight infants with apnea

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作  者:王旭莉[1] 杨祖铭[1] 顾丹凤[1] 冯宗太[1] 

机构地区:[1]南京医科大学附属苏州医院新生儿科,江苏苏州215002

出  处:《实用临床医药杂志》2016年第7期102-104,共3页Journal of Clinical Medicine in Practice

摘  要:目的探讨温湿化高流量鼻导管通气治疗极低出生体质量儿呼吸暂停的有效性与安全性。方法将41例临床诊断为呼吸暂停的极低出生体质量儿以半随机原则分为温湿化高流量鼻导管通气组(研究组)和鼻塞式持续气道正压通气组(对照组),比较2组治疗有效性与安全性。结果 2组治疗有效率、无创通气时间比较无显著差异(P>0.05)。2组气漏、喂养不耐受、坏死性小肠结肠炎、继发感染、颅内出血、动脉导管未闭合、早产儿视网膜病、支气管肺发育不良等发生率比较无显著差异(P>0.05),但研究组的鼻部损伤发生率显著低于对照组(P<0.05)。结论温湿化高流量鼻导管通气治疗极低出生体质量儿呼吸暂停的有效性与鼻塞式持续气道正压通气相当,但安全性更高。Objective To investigate the efficacy and safety of heated humidified high-flow nasal cannula in treatment of very low birth weight infants with apnea. Methods Forty-one very low birth weight infants diagnosed as apnea were qusia-randomly divided into heated humidified high-flow nasal cannula group( study group) and nasal continuous positive airway pressure group( control group). The therapeutic effect and safety were compared between two groups. Results There were no significant differences in duration of non-invasive ventilation and therapeutic effect between two groups( P〈0. 05). There were no significant differences in incidence rates of pneumothorax,feeding intolerance,NEC,secondary infection,IVH,PDA,ROP,BPD between two groups,but the incidence rate of nasal injury in the study group was significantly lower than that in the control group.Conclusion The effect of heated humidified high-flow nasal cannula is similar to nasal continuous positive airway pressure in treatment of very low birth weight infants with apnea,but and the safety of is heated humidified high-flow nasal cannula higher.

关 键 词:温湿化高流量鼻导管通气 经鼻持续性气道正压通气 呼吸暂停 极低出生体质量儿 

分 类 号:R441.8[医药卫生—诊断学]

 

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