肺炎支原体肺炎患儿免疫功能的变化及其与病情程度和疾病分期的关系  

Changes of immune function in children with mycoplasma pneumoniae pneumonia and its relationship with disease degrees and staging

作　　者：杨香红[1] 李艳莉[1] 罗春玉[1] 

机构地区：[1]赤峰学院附属医院儿科,内蒙古赤峰024000

出　　处：《实用临床医药杂志》2016年第7期113-116,共4页Journal of Clinical Medicine in Practice

摘　　要：目的探讨肺炎支原体肺炎(MPP)患儿免疫功能的变化及其与病情程度和疾病分期的关系。方法选取105例MPP患儿作为观察组,另选同期至本院体检的健康儿童100例作为对照组,依据病情程度将观察组患儿分为重症36例和轻症69例,再依据疾病分期将观察组患儿分为急性期和恢复期。比较不同病情及分期患儿以及对照组之间血清免疫球蛋白A(Ig A)、Ig M、Ig G,补体C3、C4,外周血中T淋巴细胞亚群CD_3^+、CD_4^+、CD_8^+、CD_4^+/CD_8^+水平,白介素-2(IL-2)、IL-8、IL-10、肿瘤坏死因子-α(TNF-α)以及可溶性细胞间黏附分子-1(s ICAM-1)水平的差异。结果重症和急性期患儿各指标均与对照组有不同程度的差异,重症与轻症患儿之间、急性期与恢复期患儿之间各指标亦存在不同程度的差异。结论 MPP患儿存在不同程度的体液免疫和细胞免疫功能紊乱,且急性期和病情较重的情况下机体免疫功能紊乱的情况越严重,其血清浓度的变化可反映病情程度和疾病分期。Objective To explore the changes of immune function in children with mycoplasma pneumoniae pneumonia（ MPP） and its relationship with disease degrees and staging. Methods A total of 105 children with MPP were collected as observation group,and 100 healthy children with physical examination at the same time were selected as control group. According to disease degrees,the children in observation group were divided into 36 severe cases and 69 mild cases. According to disease stagings,they were assigned into acute stage and recovery stage. The levels of serum immune globulin A（ Ig A）,Ig M and Ig G,complement C3 and C4,T lymphocyte subgroups（ CD_3~＋,CD_4~＋,CD_8~＋and CD_4~＋/ CD_8~＋） in peripheral blood,interleukin-2（ IL-2）,IL-8,IL-10,tumor necrosis factor-α（ TNF-α） as well as soluble intercellular adhesion molecule-1（ s ICAM-1） were compared among the children with different disease degrees and stagings as well as control group. Results Compared with control group,the differences were found by varying degrees between the children with severe MPP and those in acute stage in terms of each index. Differences of different degrees were also presented between the children with severe and mild MPP and those in acute and recovery stages,respectively. Conclusion The children with MPP have different degrees of disordered humoral immunity and cellular immune function,and the body immune dysfunction is more severe in acute stage or under the condition of disease severity. The changes of serum concentration can reflect the disease degree and staging.

关 键 词：肺炎支原体 小儿 免疫功能 细胞免疫 体液免疫 细胞因子 

分 类 号：R375[医药卫生—病原生物学]