肾移植术后他克莫司所致不良反应的危险因素研究  

Ressearch on Risk Factors of Adverse Reactions Caused by Tacrolomus in Renal Transplant Recipients

作　　者：欧阳萌[1,2] 辛华雯[1] 唐霞[1,3] 

机构地区：[1]广州军区武汉总医院,武汉430070 [2]湖北中医药大学 [3]南昌大学

出　　处：《中国药师》2016年第5期892-895,共4页China Pharmacist

基　　金：湖北省自然科学基金项目(编号:2009CBD010;2011CDC074)

摘　　要：目的：了解肾移植术后他克莫司所致不良反应的发生情况,分析与其发生相关的危险因素。方法：以1997~2013年在广州军区武汉总医院进行肾移植术并在术后服用他克莫司的280例患者为研究对象,对他克莫司相关的不良反应及其危险因素进行统计分析。结果：280位入选的肾移植患者中,不良反应发生率为39.65%,主要的不良反应事件为血液毒性、高血糖及高血脂。单因素统计结果发现年龄、体质量、体质指数（BMI）及用药疗程为他克莫司相关不良反应的可疑危险因素,多因素统计分析发现年龄、BMI及用药疗程是他克莫司发生不良反应的危险因素。结论：肾移植术后他克莫司所致不良反应发生率较高,当患者为高龄、营养状态差及长时间用药的情况可一定程度上增加不良反应的发生率。Objective：To study the characteristics of the adverse reactions caused by tacrolimus and analyze the risk factors.Methods：Totally 280 cases of renal transplant recipients received standard treatment options were selected from 1997 to 2013 in Wuhan general hospital of Guangzhou military command.The tacrolimus-related adverse reactions and their risk factors were analyzed statistically.Results：Totally 39.65% of the patients had the tacrolimus-related adverse reactions.The main adverse reactions were hematotoxicity,diabetes mellitus and hyperlipidemia.The univariate analysis showed that age,weight,BMI and treatment course were the suspected risk factors.The multivariate analysis results showed that age,BMI and treatment course were the risk factors of tacrolimus-related adverse reactions.Conclusion：The incidence of tacrolimus-related adverse reactions is relatively high,and if the patient is in advanced age,with poor nutritional status or long-term medication,the probability of adverse reactions will be increased.

关 键 词：他克莫司 肾移植 药品不良反应 危险因素 

分 类 号：R979.5[医药卫生—药品]