重楼植物中内生菌研究进展  

Research Progress in Endophyte in Rhizoma Paridis

作　　者：何秀丽[1] 丁嫚嫚 叶方[1,2] 黄良永[1,2] 雷攀[1] 

机构地区：[1]湖北医药学院附属十堰市太和医院,湖北十堰442000 [2]湖北医药学院

出　　处：《中国药师》2016年第5期970-973,共4页China Pharmacist

基　　金：湖北省2011计划项目(编号:4);2014年湖北省中青年创新团队项目(编号:T201414);湖北省药用植物综合利用工程技术研究中心项目(编号:GC2015204)

摘　　要：重楼植物的内生菌主要有内生细菌和内生真菌。重楼的内生菌有多种生理活性,如抑制其他微生物活性、抗肿瘤细胞活性等作用,部分内生菌发酵液可产生宿主重楼植物中主要活性物质甾体皂苷;能使万古霉素、孕酮化合物等结构发生转化。重楼中内生菌的这些特性可能增加重楼抗病能力、抵御生长环境协迫能力、提高重楼产率、转化或修饰重楼中活性次生代谢产物或其他化合物等,因此,研究重楼中内生菌的分离、鉴别、筛选、克隆等对开辟药物研发新途径、缓解中药资源短缺等方面具有重要的意义。The endogenous microorganism in paridis rhizoma mainly includes bacteria and fungi,and shows different physiological activities,such as microorganism inhibition and anti-tumor activity.The principal active substance steroid saponin in paridis rhizoma can be generated from the fermentation liquor of some endogenous bacteria,and the chemical structure of vancomycin and progesterone can be transformed by the endophyte.It is supposed that paridis rhizoma may benefit from the attributions of the endogenous bacteria against illness and environment changes.It would also benefit in productivity,transformation and modification of the other active sub-metabolites and compounds in paridis rhizoma.Thus,it is valuable in drug development and source insufficiency alleviation of Chinese medicines through separation,identification,screening and clone of the endogenous microorganism in paridis rhizoma.

关 键 词：重楼 内生菌 生物活性 重楼皂苷 

分 类 号：R282.71[医药卫生—中药学]