沙利度胺的临床新应用与不良反应研究概述  

New Clinical Application and Adverse Reactions of Thalidomide

作　　者：裴丽[1] 罗艳[1] 黄显金[1] 王丽伟[1] 刘京伟[1] 

机构地区：[1]解放军总医院第一附属医院药剂药理科,北京100048

出　　处：《中国药师》2016年第5期977-980,共4页China Pharmacist

摘　　要：目的:分析沙利度胺的不良反应(ADRs)和临床应用,为临床合理用药提供参考。方法:系统回顾国外有关沙利度胺的临床文献报道,并进行分析整理。结果:沙利度胺的不良反应涉及胃肠道反应、血液毒性、心血管毒性、神经毒性、皮肤损害、肺栓塞等。此外,其新的临床应用也较为广泛。结论:临床医师及药师应重视沙利度胺的用药风险与合理用药,以保障临床用药安全、有效。Objective：To analyze the adverse drug reactions（ADR） and clinical application of thalidomide to provide useful reference for rational medication in clinics.Methods：The case reports and literatures from foreign countries on the clinical medication of thalidomide were analyzed and summarized.Results：The ADR of thalidomide included gastrointestinal reaction,hematotoxicity,cadiovascular toxicity,neurotoxicity,skin lesion,pulmonary embolism and so on.Its new medication methods were widely used in clinics.Conclusion：Clinicians and pharmacists should pay more attention to the medication risks and rational use of thalidomide in order to assure the safety and effectiveness of clinical drug use.

关 键 词：沙利度胺 临床新应用 药品不良反应 合理用药 

分 类 号：R97[医药卫生—药品]