正交试验法优选红藤汤中空栓的制备工艺  

Preparation Technology Optimization of Hongteng Decoction Hollow Suppositories by Orthogonal Test

作　　者：罗德凤[1] 张芳向[1] 王芬[1] 祁兢晶[1] 邹振红 

机构地区：[1]深圳市龙岗区妇幼保健院药剂科,广东深圳518172

出　　处：《中国药师》2016年第5期1006-1008,共3页China Pharmacist

基　　金：深圳市卫生计生系统科研项目(编号:201402124)

摘　　要：目的:确立红藤汤中空栓的最佳制备工艺。方法:通过正交试验优化处方制备工艺,以药物与基质的比例(A)、含药基质灌模温度(B)及脱模时间(C)为考察因素,以外观质量和融变时限为考察指标,对中空栓剂制备工艺条件进行优选。结果:最优的处方工艺为药物与基质的比例1∶2、含药基质灌模温度:40℃、脱模时间:30 min。结论:本方法确定的红藤汤中空栓制备工艺稳定可行。Objective：To establish an optimum preparation process for Hongteng decoction hollow suppositories.Methods：An orthogonal design was performed to screen the proportion of drug and base（A）,the temperature of mold filling with drug and base（B） and stripping time（C）,and the appearance and melting time were used as the indices,the best preparation technology of the hollow suppositories was optimized.Results：The optimum preparation technology of the hollow suppositories was as follows：the proportion of drug and base was 1 ∶2,the filling temperature was 40℃,and the stripping time was 30 min.Conclusion：The optimum preparation technology of Hongteng decoction hollow suppositories is simple and feasible.

关 键 词：红藤汤 中空栓 制备工艺 正交试验 

分 类 号：R283.6[医药卫生—中药学]