复方二氧化钛乳膏基质处方的筛选  

Screening of the Base Formula of Compound Titanium Dioxide Cream

作　　者：孙华燕[1] 李婕[1] 徐风华[1] 

机构地区：[1]解放军总医院制剂室,北京100853

出　　处：《中国药师》2016年第5期1019-1020,1029,共3页China Pharmacist

基　　金：军队医疗机构制剂标准提高科研专项课题(编号:13ZJZ05)

摘　　要：目的:筛选最佳的复方二氧化钛乳膏基质处方。方法:拟定5种不同处方的基质与水杨酸苯酯、二氧化钛进行配伍,制备复方二氧化钛乳膏,并考察乳膏的性状和稳定性。结果:5种非离子型乳化剂均能制备出复方二氧化钛乳膏,处方A制得的乳膏偏稠厚,处方B、C、D、E制得的乳膏细腻、有光泽、易涂布。5种乳膏离心后均未发生分层现象,且耐低温。在高温试验中,处方A和B制得的乳膏呈失水粗糙状;处方D制得的乳膏与室温放置的同类样品比较,无明显性状改变;处方C和E制得的乳膏稠度下降,成流动液体状。放置12个月,处方D制得乳膏的性状和含量没有发生明显变化。结论:处方D制得的复方二氧化钛乳膏细腻、易涂布,稳定性好,具备临床应用价值。Objective：To screen the optimal base of compound titanium dioxide cream.Methods：Phenyl salicylate and titanium dioxide were respectively combined with 5 kinds of matrices to prepare compound titanium dioxide cream.The properties and stability of compound titanium dioxide cream were studied.Results：The 5 kinds of anionic emulsifiers all could be used to prepare compound titanium dioxide cream.The cream prepared with formula A was thick,and the cream prepared with formula B,C,D and E were delicate,luster and easy to smear.After the centrifugal test and low temperature test,the cream had no obvious changes.After the high temperature test,the cream prepared with formula A and B was dry and rough,the cream prepared with formula D had no significant changes when compared with that stored under room temperature,and the cream prepared with C and E was attenuated and changed into solution.Stored under the room temperature for 12 months,the cream prepared with formula D had no changes in the content and properties.Conclusion：Compound titanium dioxide cream prepared formula D is delicate and easy to smear with good stability,which shows good clinical application value.

关 键 词：二氧化钛 水杨酸苯酯 乳膏 基质 

分 类 号：R944.21[医药卫生—药剂学]