Convenient Synthesis of Spiro[benzo[d]pyrrolo[2,1-b]thiazole- 3,2＇-indenes] Derivatives via Three-Component Reaction  

作　　者：Guoliang Shen Jing Sun Chaoguo Yan 

机构地区：[1]College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002, China

出　　处：《Chinese Journal of Chemistry》2016年第4期412-418,共7页中国化学（英文版）

摘　　要：The three-component reaction of N-phenacylbenzothiazolium bromides, aromatic aldehydes and indane-l,3- dione in ethanol at room temperature in the presence of triethylamine as base afforded functionalized spiro[benzo- [d]pyrrolo[2,1-b]thiazole-3,2＇-indenes] in good yields and with high diastereoselectivity. The 1H NMR data and sin- gle crystal structure clearly indicated that the obtained spiro compounds predominately have one diastereoisomer.The three-component reaction of N-phenacylbenzothiazolium bromides, aromatic aldehydes and indane-l,3- dione in ethanol at room temperature in the presence of triethylamine as base afforded functionalized spiro[benzo- [d]pyrrolo[2,1-b]thiazole-3,2＇-indenes] in good yields and with high diastereoselectivity. The 1H NMR data and sin- gle crystal structure clearly indicated that the obtained spiro compounds predominately have one diastereoisomer.

关 键 词：multicomponent reaction nitrogen ylide spiro compound BENZOTHIAZOLE indan-1 3-dione 

分 类 号：TQ638[化学工程—精细化工] O626[理学—有机化学]