窒息新生儿血清胱抑素C和尿微量白蛋白检测的临床意义  

Clinical significance of serum cystatin C and urine microalbumin detection in neonatal asphyxia

作　　者：邱汉银[1] 

机构地区：[1]东莞市人民医院儿科,523000

出　　处：《中国实用医药》2016年第9期20-21,共2页China Practical Medicine

摘　　要：目的探讨窒息新生儿血清胱抑素C(Cys C)和尿微量白蛋白(UMA)联合检测的临床意义。方法 57例窒息新生儿,其中轻度窒息31例为轻度窒息组,重度窒息26例为重度窒息组,另选同期25例健康新生儿为对照组,分别于生后24 h内采集静脉血、生后2 d采集尿液检测血清Cys C和UMA水平。对比三组检测结果。结果新生儿轻度窒息组和重度窒息组血清Cys C及UMA水平均较对照组明显升高,差异均有统计学意义(P<0.01),重度窒息组Cys C及UMA水平明显高于轻度窒息组,差异均有统计学意义(P<0.01)。结论窒息新生儿血清Cys C和UMA水平与病情严重程度及肾功能损害密切相关,联合检测两者水平对窒息新生儿肾损害的早期诊断有重要价值。Objective To investigate clinical significance of serum cystatin C（Cys C） and urine microalbumin（UMA） by combined detection in neonatal asphyxia. Methods Among 57 newborn with neonatal asphyxia, there were 31 cases with mild asphyxia as mild asphyxia group, and 26 cases with severe asphyxia as severe asphyxia group. There were another 25 healthy newborn at the same period as control group. Their venous blood and urine were respectively taken in postnatal 24 h and 2 d for serum Cys C and UMA levels detection. Outcomes of detection were compared across the three groups. Results The mild asphyxia group and severe asphyxia group had obviously higher serum Cys C and UMA level than the control group, and their differences all had statistical significance（P〈0.01）. The severe asphyxia group had much higher serum Cys C and UMA level than the mild asphyxia group, and the differences all had statistical significance（P〈0.01）. Conclusion Serum Cys C and UMA level in neonatal asphyxia are closely related with severity and renal damage. Combined detection contains important value for early diagnosis of renal damage in neonatal asphyxia.

关 键 词：新生儿窒息 肾损害 血清胱抑素C 尿微量白蛋白 

分 类 号：R722.12[医药卫生—儿科]