甘酸缓急方对高血压肝阳上亢型肾素-血管紧张素-醛固酮系统的影响  

Effect of Gansuan Huanji Formulas on the Renin-Angiotensin-Aldosterone System in Hypertension of Liver Yang Hyperactivity type

作　　者：王健[1] 王振强[1] 张万辉[1] 穆凤娟[1] 

机构地区：[1]河北省沧州市中西医结合医院,河北沧州061001

出　　处：《山东中医杂志》2016年第5期387-390,共4页Shandong Journal of Traditional Chinese Medicine

基　　金：沧州市科学技术计划项目(编号131302198);河北省中医药管理局科研项目(编号2014351)

摘　　要：目的 :观察甘酸缓急方治疗原发性高血压肝阳上亢型的临床疗效及其对肾素-血管紧张素-醛固酮系统(RAAS)活性的影响。方法:选取128例轻、中度高血压患者随机分为甘酸缓急方治疗组和西医治疗对照组,两组均予以氨氯地平口服,治疗组加用甘酸缓急方,治疗4周后,观察两组中医证候积分、诊室血压以及血浆肾素(PRA)、血管紧张素Ⅱ(AngⅡ)、醛固酮(ALD)水平的变化情况。结果:与治疗前相比,两组中医证候积分、诊室血压均明显改善(P<0.05);与对照组相比,治疗组中医证候积分、诊室血压改善更加明显(P<0.01),PRA、AngⅡ、ALD下降更加显著(P<0.05)。结论:在西医治疗基础上加用甘酸缓急方能进一步抑制RAAS系统的活性,降低血压,改善临床症状。Objective：To observe the clinical effect of Gansuan Huanji formulas on the rennin-angiotensin-aldosterone system（RAAS） in the patients with hypertension of liver Qang hyperactivity type.Methods：There were 128 cases of patients with mild and moderate hypertension randomly divided into treatment group and the control group. Both groups were treated with amlodipine orally,while the treatment group was also given Gansuan Huanji formulas, After 4 weeks of treatment,in the two groups changes of traditional Chinese medicine（TCM） syndrome score,clinical blood pressure,plasma renin activity（PRA）,angiotensin Ⅱ （Ang Ⅱ） and aldosterone（ALD） were observed, Result：After the treatment,TCM syndrome score and clinical blood pressure of two groups were significantly i＇mproved（P〈0.05）;in the treatment group,TCM symptom score and clinical blood pressure were changed more obviously than the control group（P〈0.05）,and PRA,Ang Ⅱand ALD were redUced more significantly than the control group（P〈0.05）： Conclusion：The use of Gansuan Huanji formula in combination with western medicine can inhibit the activity of RAAS,reduce blood pressure and improve clinical symptoms.

关 键 词：甘酸缓急方 原发性高血压 肝阳上亢型 动态血压 肾素-血管紧张素-醛固酮系统活性 

分 类 号：R259.441[医药卫生—中西医结合]