聚乙二醇干扰素治疗对慢性乙型肝炎患者Th17/Treg的影响  

Effect of Polyethylene Glycol(peg) Interferon Therapy on Th17/Treg in Patients with Chronic Hepatitis B

作　　者：阚延婷 甘建和[1] 孙蔚[1] 冯婷婷[1] 吴云辉[1] 苏兰[1] 

机构地区：[1]苏州大学附属第一医院传染科,江苏苏州215006

出　　处：《现代生物医学进展》2016年第13期2490-2492,2480,共4页Progress in Modern Biomedicine

基　　金：国家"十二五"科技重大专项(2012ZX10002004-008)

摘　　要：目的:研究聚乙二醇干扰素抗病毒治疗对慢性乙型肝炎(CHB)患者Th17、Treg及Th17/Treg的影响,及Th17/Treg与表面抗原的关系。方法:30例HBe Ag阴性慢性乙型肝炎患者予聚乙二醇干扰素治疗,在治疗前与治疗后24周、48周时,检测外周血Th17、Treg的细胞频数及表面抗原定量,并与20例健康人的Th17、Treg的细胞频数进行比较,分析聚乙二醇干扰素对Th17、Treg的影响。结果:1CHB患者的Th17及Treg细胞频数较健康人的高,但Th17/Treg比例较健康人低。抗病毒治疗后24周时,Th17/Treg比例较治疗前升高,48周时Th17/Treg比例较24周时稍降低(P>0.05),48周时与治疗前相比仍升高(P<0.05)。2治疗结束时表面抗原阴转病人的Th17/Treg比未阴转病人高。3慢乙肝病人的Th17/Treg与表面抗原定量成负相关(r=-0.388,P<0.05)。结论:CHB患者体内存在着Th17/Treg的失衡,干扰素可以调节CHB患者的免疫功能,有望实现表面抗原阴转。Objective： To study the impact of polyethylene glycol （peg） interferon antiviral treatment on Thl17 and Treg and Th17 / Treg in patients with chronic hepatitis B （CHB）, and investigate the relationship between Th17 / Treg and the surface antigen. Methods： 30 cases of HBeAg negative chronic hepatitis B patients were treated with polyethylene glycol （peg） interferon. The level of Th17 and Treg cells frequency and surface antigen quantity was detected before treatment and 24 weeks and 48 weeks after treatment. Another 20 cases of healthy people was selected as control. Th17 and Treg cells frequency was compared between two groups, and the effect of polyethylene glycol （peg） interferon on Th17 and Treg was analyzed. Results： The frequency of of Th17 and Treg cells were higher in CHB patients than that of healthy people, the proportion of Th 17 / Treg was lower than those of healthy people. After 24 weeks of antivi- ral treatment, the proportion of Th17 / Treg was increased, the percentage of Th17 / Treg at 48 weeks were slightly lower than at 24 weeks （P〉0.05）, and it was still higher at 48 weeks compared with before treatment （P 〈 0.05）. At the end of the treatment, Thh17 / Treg of the patient with surface antigen negative change was higher than the patients without negatively change. There was negative correla- tion between Th17 / Treg and surface antigen quantitative （r =- 0.388 ）, P 〈 0.05）. Conclusions： Patients with CHB presented Th17 / Treg imbalance, and interferon treatment can adjust the immune function of patients with CHB, is expected to achieve the surface antigen neg- ative change.

关 键 词：慢性乙型病毒性肝炎 干扰素 免疫调控 TH17/TREG HBsAg阴转 

分 类 号：R512.62[医药卫生—内科学]