硫辛酸对2型糖尿病患者SOD、MDA及hs-CRP水平的影响  

Effects of alpha-lipoic acid on serum SOD,MDA and hs-CRP in type 2 diabetic patients

作　　者：曾瑞翔 张冰雨[1] 雷涛[2] 

机构地区：[1]同济大学附属同济医院内分泌科,上海200065 [2]上海中医药大学附属普陀医院内分泌科,上海200062

出　　处：《同济大学学报（医学版）》2016年第2期40-43,共4页Journal of Tongji University(Medical Science)

基　　金：国家"八六三"高技术研究发展计划(2014AA022304);上海市卫生局科研基金(20124256)

摘　　要：目的探讨α-硫辛酸对2型糖尿病患者血清超氧化物歧化酶(SOD)、丙二醛(MDA)及超敏C反应蛋白(hs-CRP)水平的影响。方法选择120例2型糖尿病患者按照治疗方法不同随机分为治疗组和对照组各60例,两组均给予常规降糖药物/胰岛素等治疗,治疗组在此基础上加用α-硫辛酸,连续治疗2周后评价患者血清SOD、MDA、hs-CRP水平变化,治疗结束后3个月再次复查患者血清SOD、MDA、hs-CRP水平并对比其变化。结果治疗14 d后治疗组SOD、MDA、hs-CRP水平明显改善,与治疗前及对照组比较差异具有统计学意义(P<0.05);治疗结束后3个月两组患者SOD、MDA、hs-CRP含量的差异具有统计学意义(P<0.05)。在治疗组中,治疗14 d后与治疗后3个月相比,SOD、MDA的差异具有统计学意义(P<0.05),hs-CRP的差异不具统计学意义(P>0.05)。结论α-硫辛酸在2型糖尿病的治疗中有利于改善机体氧化应激反应、降低炎性递质水平,对于改善预后、延缓相关并发症的发生发展具有重要意义。Objective To investigate the influence of α-lipoic acid on serum SOD, MDA and hs- CRP levels in type 2 diabetic patients. Methods One hundred and twenty type 2 diabetic patients were randomly divided into two groups with 60 cases in each. Patients in both groups received conventional hypoglycemics/insulin therapy, and α-lipoic acid was added in patients of observation group. Serum SOD, MDA and hs-CRP were determined before treatment and 2 weeks and 3 months after treatment. Results After 2 weeks of treatment, serum SOD was significantly increased, serum MDA and hs-CRP were significantly decreased in α-lipoic acid group compared to same group before treatment and the control group after treatment （ all P 〈 0.05 ）. There were significant differences in serum SOD andMDA levels of a-lipoic acid group between those at 2 weeks and at 3 months after treatment （P 〈 0. 05）, but no significant difference in hs-CRP levels （P 〉 0.05 ）. Conclusion α- lipoic acid can reduce the oxidative stress response and inflammatory mediator levels in type 2 diabetic patients receiving conventional treatement.

关 键 词：2型糖尿病 Α-硫辛酸 超氧化物歧化酶 丙二醛 超敏C反应蛋白 

分 类 号：R587.1[医药卫生—内分泌]