外周血白细胞升高与代谢综合征的关系  

Association of white blood cell count and metabolic syndrome

作　　者：宋娟[1,2] 雷涛[1] 

机构地区：[1]同济大学附属同济医院内分泌科,上海200065 [2]上海交通大学医学院附属新华医院崇明分院内分泌科,上海202150

出　　处：《同济大学学报（医学版）》2016年第2期44-48,共5页Journal of Tongji University(Medical Science)

基　　金：国家"八六三"高技术研究发展计划(2014AA022301)

摘　　要：目的 探讨外周血白细胞（white blood cell,WBC）计数与代谢综合征（metabolic syndrom,MS）各心血管危险因子的相关性。方法 采用随机整群抽样方法,对崇明县城桥镇40~70岁3 249名常住居民进行调查,内容包括问卷调查、体格检查、75 g葡萄糖口服耐量试验、血常规和血脂、血糖、尿酸（uric acid,UA）、谷丙转氨酶（alanine aminotransferase,ALT）等生化检查。分析WBC升高与收缩压（systolic blood pressure,SBP）、舒张压（diastolic blood pressure,DBP）、腰围（waist circumference,WC）、血糖、血脂、UA、尿微量白蛋白（urinary microalbumin,Um Alb）、ALT的关系。结果 参与体检者3 249名,资料填写齐全者共3 149名,占应调查人群的96.92%,占崇明地区人口64.45/万,其中男性921名（29.25%）,女性2 228名（70.75%）,平均年龄（55.62±7.92）岁。按是否有MS,分为MS组（1 160例）和对照组（1 898例）。MS组WBC计数明显高于对照组。WBC计数与不同MS心血管危险因子比较,随着MS代谢组分增多,WBC计数逐渐升高（F=33.986,P〈0.000 1）。Logistic回归分析显示WBC升高与WC、空腹血糖（fasting blood glucose,FPG）、餐后2 h血糖（2 h plasma glucose,2h PG）、SBP、DBP、高密度脂蛋白胆固醇（high density lipoprotein,HDL-C）、三酰甘油（triglyeride,TG）、UA有显著相关性（P〈0.000 1）。结论 作为炎症因子的WBC与MS心血管危险因子有较强的相关性,WBC参与了MS的慢性炎症过程。Objective To study the association of white blood cell （WBC） count with metabolic syndrome （MS） and its cardiovascular risk factors. Methods A cross-sectional survey with multiple stage stratified cluster and random sampling were performed. All residents aged from 40 to 70 were invited to participate the survey in Chengqiao Township of Chongming County. Questionnaire, physical examination, serum lipid-profile, 75 g oral glucose tolerance test and routine blood test were performed in all subjects. The association of WBC count with MS and its risk factors was analyzed. Results A total of 3 249 residents participated the survey accounting for 64.45/10 000 of total residents in Chongming County. Of the 3 149 residents surveyed, 921 were males （29.25%） and 2 228 were females （70.75%）. The mean age of the participants was （55.62 ±7.92 ） years and ranged from 40 - 70 years. Among all subjects 1 160 were diagnosed as MS and 1 898 as non-MS （ control group）. The level of the WBC count was significantly higher in MS group than that in control group. With a increasing numbers of cardiovascular risk factors, white blood cell count also raised （F = 33.986, P 〈 0. 000 1 ）. Logistic regression analysis showed that WC, FPG, 2hPG, SBP, DBP, HDL-C, TG, UA were positively correlated with WBC （ P 〈 0. 000 1 ）. Conclusion The WBC count, as a classic inflammatory marker, is correlated with MS and its cardiovascular risk factors.

关 键 词：WBC计数 代谢综合征 慢性炎症 心血管危险因子 

分 类 号：R589[医药卫生—内分泌]