衰老在慢性阻塞性肺疾病发病中的作用  

Research progress in chronic obstructive pulmonary disease caused by senescence

作　　者：汪琦[1] 王桦[1] 吴晓玲[1] 

机构地区：[1]武汉大学中南医院老年病科,430071

出　　处：《国际呼吸杂志》2016年第9期704-708,共5页International Journal of Respiration

摘　　要：COPD是全球主要的公共卫生问题，严重影响患者的生活质量。衰老涉及细胞衰老氧化应激、炎性衰老、端粒缩短、衰老与抗衰老失衡等方面。越来越多的研究表明，衰老是驱使COPD的一个重要因素。该文就衰老在COPD发生、发展中的作用进行综述。Chronic obstruction pulmonary disease （COPD） is a major global public health problem, which has a serious impact on the quality of life of patients. Senescence involves cellular senescence, oxidative stress, inflammatory aging, telomere shortening, out of-balance between senescence and anti- senescence, ect. More and more studies have indicated that senescence is considered as an important contributing factor in driving COPD. Here is to make a review of the effect of senescence in COPD.

关 键 词：慢性阻塞性肺疾病 衰老 抗衰老 氧化应激 

分 类 号：R563.9[医药卫生—呼吸系统]