湖北青砖茶对IBS-D模型大鼠肠道敏感性的影响  

The Effects of Hubei Qingzhuan Tea on Intestinal Sensitivity in IBS-D Mouse Model

作　　者：李世刚[1,2] 郑倩倩[2] 何建刚 肖长义[1,2] 柳蔚[1,2] 王慧[1,3] 刘锦程 

机构地区：[1]湖北长盛川青砖茶研究所,湖北宜昌443002 [2]三峡大学医学院,湖北宜昌443002 [3]三峡大学生物工程与制药工程学院,湖北宜昌443002

出　　处：《茶叶科学》2016年第3期245-249,共5页Journal of Tea Science

摘　　要：研究了湖北青砖茶对腹泻型肠易激综合征(IBS-D)模型大鼠肠道的影响。结果表明,与正常组相比,模型组的痛阈值明显降低,血清中炎症因子前列腺素2(PGE2)、肿瘤坏死因子(TNF-α)、类胰蛋白酶的含量明显增加;与模型组比较,湖北青砖茶低剂量组、高剂量组能够显著升高痛阈值,而血清中炎症因子PGE2、TNF-α、类胰蛋白酶的含量显著降低,且具有剂量依赖性。由此表明湖北青砖茶可降低IBS-D模型大鼠的肠道敏感性,其作用机制可能与血清中PGE2、TNF-α和类胰蛋白酶含量的降低有关。The effects of Hubei Qingzhuan tea on intestinal sensitivity in IBS-D mouse model were investigated. The results showed, compared with the normal group, the control group had a significant reduction in the pain threshold, and marked increase in the serum level of inflammatory cytokines PGE2, TNF-alpha, tryptase. Compared with the control group, both the low and high dose of Qingzhuan tea significantly increased the pain threshold and markedly decreased the serum level of inflammatory cytokines PGE2, TNF-alpha, tryptase by a dose dependent manner. It is concluded that Qingzhuan tea could significantly decrease the intestinal sensitivity of IBS-D mice, which might be related to the inhibition of serum PGE2, TNF-alpha and tryptase levels.

关 键 词：湖北青砖茶 IBS-D 肠道敏感性 结肠组织 炎症因子 

分 类 号：R285.5[医药卫生—中药学]