稽留流产患者抗心磷脂抗体和抗β2糖蛋白I抗体的检测及临床意义  

Detection and clinical significance of anti-cardiolipin and anti-β2 glycoprotein I antibodies in missed abortion women

作　　者：陈芳[1] 方杰[2] 王婷[1] 夏龙飞[1] 马小艳[3] 施卫东[1] 眭建[1] 

机构地区：[1]江苏大学医学院,江苏省镇江市212000 [2]江苏大学附属医院妇科 [3]江苏大学附属医院产科

出　　处：《中国综合临床》2016年第4期304-307,共4页Clinical Medicine of China

基　　金：中国学位与研究生教育学会立项课题（2015Y0603）

摘　　要：目的探讨抗心磷脂抗体（aCL）和抗β2糖蛋白I抗体（anti-β2GPI）与稽留流产之间的关系。方法选取14例稽留流产患者为试验组，20例自愿终止妊娠的正常早孕患者为对照组，采用化学发光免疫分析法（CLIA）定量检测两组患者血清IgG／IgM抗心磷脂抗体和IgG／IgM抗β2糖蛋白I抗体水平。结果试验组血清IgMaCL中位水平及血清IgManti-β2GPI中位水平与对照组比较差异均有统计学意义[IgMaCL中位水平：21．3（2．2～39．4）KU／L与6．0（1．5～10．7）KU／L，IgManti-β2GPI中位水平：11．9（1．2～25．4）KU／L与1．9（1．1—4．0）KU／L；U值分别为2．031、2．912，P均〈0．05]。两组血清IgGaCL水平及血清IgGanti-β2GPI水平比较差异均无统计学意义（P均〉0．05）。结论IgM抗心磷脂抗体和IgM抗β2糖蛋白I抗体与稽留流产有相关性，提示育龄期妇女，早期和动态检测抗心磷脂抗体和抗β2糖蛋白I抗体对降低稽留流产的发生率有一定临床意义。Objective To investigate the correlation of the anti-cardiolipin （aCL） antibodies and anti- β2 glycoprotein I（anti-β2GPI） antibodies in missed abortion women. Methods Fourteen patients diagnosed missed abortion were chose as trial group, while 20 normal females received induced abortion in the same time as control group. Chemiluminescence method was used to measure the serum levels of IgG/IgM aCL and IgG/IgM anti-β2GPI antibodies in the two groups. Results The median levels of serum IgM aCL antibodies and serum IgM anti-β2GPI antibodies in trial group were significantly higher than those of control group（ 21.3（ 2. 2-39.4） KU/L vs. 6. 0（ 1.5- 10. 7） KU/L, 11.9 （ 1.2- 25.4） KU/L vs. 1.9 （ 1.1 - 4. 0） KU/L; u = 2. 031,2. 912 ; P 〈0. 05）. There were no significant differences in terms of the levels of serum IgG aCL antibodies and serum IgG anti-β2GPI antibodies between trial group and control group （P〉 0. 05） . Conclusion There is correlation between IgM aCL as well as IgM anti-β2GPI antibodies and missed abortion, so in reducing the incidence of missed abortion,early and dynamic detection of anti-cardiolipin and anti-β2 glycoprotein I antibodies in child- beating women has a certain clinical significance.

关 键 词：稽留流产 抗心磷脂抗体 抗Β2糖蛋白I抗体 

分 类 号：R593.241[医药卫生—内科学]