血清可溶性白细胞介素2受体与可溶性肿瘤坏死因子受体Ⅱ在结节病肺外器官受累中的检测价值  

Application of serum soluble inerleukin-2 receptor and soluble tumor necrosis factor receptor H levels in extrapulmonary organ involvement sarcoidosis

作　　者：王晓阳[1] 王彩彩[2] 段蕴铀[1] 

机构地区：[1]第二军医大学海军临床医学院,北京100048 [2]河北省胸科医院

出　　处：《中国综合临床》2016年第4期365-368,共4页Clinical Medicine of China

摘　　要：目的探讨血清可溶性白细胞介素2受体（slL-2R）与可溶性肿瘤坏死因子受体Ⅱ（sTNFRⅡ）在结节病肺外器官受累中的检测价值。方法选取结节病活动期病例28例，分为肺外器官受累组（12例）和单纯肺部病变组（16例），抽取其外周血，并采用双抗体酶联免疫吸附试验法（ELISA）测定两组患者外周血血清中sIL．2R、sTNFRⅡ的表达水平，比较两组之间表达水平的不同。结果肺外器官受累组外周血血清中sIL-2R表达水平及sTNFRⅡ表达水平与单纯肺部病变组比较差异均有统计学意义[sIL-2R水平：（1．60±0．80）μg／L与（1．00±0．29）μg／L，sTNFRⅡ水平：（1．09±0．24）μg／L与（0．85±0．29）μg／L，t值分别为2．764、2．183，P均〈0．05]。结论外周血血清中sIL-2R、sTNFRⅡ的表达水平可能是判断结节病肺外器官受累的重要指标，可用以指导临床实践。Objective To investigate the application of serum soluble interleukin-2 receptor（sIL-2R） and soluble tumor necrosis factor receptorⅡ（sTNFR Ⅱ ） in extrapulmonary organ involvement sarcoidosis. Methods Of 28 cases with sarcoidosis which were in active period, 12 cases were in extrapulmonary organ involvement subgroup, 16 cases were in pure pulmonary lesions subgroup. Serum sIL-2R and sTNFR Ⅱ of the two groups were detected by enzyme linked immunosorbent assay and compared. Results The expression level of sIL-2R in extrapulmonary organ involvement subgroup was （ 1.60 ± 0. 80 ） μg/L, significantly higher than that of pure pulmonary lesions group, and there was significant difference（ （ 1.00±0. 29） μg/L,t = 2. 764,P〈0. 05） ;and the expression level of sTNFR Ⅱ in extrapulmonary organ involvement subgroup was （ 1.09± 0. 24） μg/L, significantly higher than that of pure pulmonary lesions group, and the difference between the two groups was statistically significant （ （ 0. 85 ± 0. 29 ） μg/L, t = 2. 183, P 〈 0.05 ） . Conclusion The expression level of peripheral blood serum sIL-2R and sTNFR II may serve as the important indexes to judge the extrapulmonary organ involvement sarcoidosis.

关 键 词：结节病 血清可溶性白细胞介素2受体 血清可溶性肿瘤坏死因子受体Ⅱ 

分 类 号：R767.1[医药卫生—耳鼻咽喉科]