替格瑞洛与氯吡格雷对经皮冠状动脉介入术治疗的ST段抬高型心肌梗死患者的临床疗效  

Clinical effect of ticagrelor and clopidogrel on patients with ST segment elevation myocardial infarction treated with percutaneous coronary intervention

作　　者：毛霄鹏[1] 严语[2] 

机构地区：[1]东南大学附属中大医院全科医学科,南京210009 [2]东南大学附属中大医院心血管内科,南京210009

出　　处：《中国临床药理学杂志》2016年第9期786-788,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的观察ST段抬高型心肌梗死患者经皮冠状动脉介入治疗术(PCI)后应用替格瑞洛与氯吡格雷的临床疗效。方法住院接受PCI治疗的ST段抬高型心肌梗死患者231例,随机分为试验组121例与对照组110例。试验组在PCI治疗前口服替格瑞洛,起始剂量为单次负荷剂量180 mg;此后,每次90 mg,每天2次;对照组在PCI治疗前口服氯吡格雷300 mg,此后口服75 mg·d^(-1)维持。2组均治疗30 d。患者在PCI前后进行心肌梗死溶栓治疗血流分级,治疗前、治疗后30 d进行超声检查评价患者的左心功能,统计术后1个月心血管事件的发生率。结果 2组患者在术前、术后的心肌梗死溶栓治疗血流分级差异无统计学意义(P>0.05)。治疗后,2组患者心功能改善显著优于治疗前(P<0.05);试验组心血管事件发生率(8.3%)显著低于对照组(19.1%,P<0.05)。结论 ST段抬高型心肌梗死患者PCI术后应用替格瑞洛可以有效减少心血管事件的发生率,促进左心功能恢复,安全性较好。Objective To observe the clinical effect of ticagrelor and clopidogrel on patients with ST segment elevation myocardial infarction treated with percutaneous coronary intervention（ PCI）. Methods A total of 231 patients with ST segment elevation myocardial infarction treated by PCI were randomly divided into treatment group（ n = 121） and control group（n = 110）. Treatment group was received ticagrelor treatment,180 mg before PCI and 90 mg·d^-1 ,two times a day after PCI; control group received clopidogrel treatment,300 mg before PCI and 75 mg·d^-1 after PCI. Two groups were treated for 30 d. Before and after PCI,patients were received thrombolysis in myocardial infarction blood flow classification. Before and 30 d after PCI,patients＇ left heart function was evaluated. The incidence of cardiovascular events in one month after PCI was evaluated. Results There was no significant difference between the two groups before and after PCI treatment on blood flow classification（ P〈0. 05）. The incidence of cardiovascular events in treatment group（8. 3%） was lower than that in control group（19. 1%,P〈0. 05）. Left ventricular function recovery in treatment group was better than control group（ P〈0. 05）. Conclusion The application of ticagrelor on patientswith ST segment elevation myocardial infarction received PCI treatment can more effectively reduce cardiovascular events,promote left ventricular function recovery,also safety.

关 键 词：ST段抬高型心肌梗死 经皮冠状动脉介入治疗术 替格瑞洛 氯吡格雷 心血管事件 左心功能 

分 类 号：R973[医药卫生—药品]