慢性肾疾病和尿毒症毒素对非肾清除影响的研究进展  

Progress on the influence of chronic kidney disease and uremic toxin on non-renal clearance of drugs

作　　者：马婉乐 孙雪[1,2] 喻婉莹[1,2] 况赟 龚丽英[1] 阳国平[1] 

机构地区：[1]中南大学湘雅三医院临床药理中心,长沙410013 [2]中南大学药学院,长沙410013

出　　处：《中国临床药理学杂志》2016年第9期861-864,共4页The Chinese Journal of Clinical Pharmacology

基　　金：国家"重大新药创制"科技重大专项基金资助项目(2012ZX09303014-001);科技部国际科技合作与交流专项基金资助项目(2014DFA30900)

摘　　要：慢性肾疾病不仅影响经肾消除的药物的药代动力学和药效学,也会影响药物的非肾清除。慢性肾疾病能够影响肝和肠道的药物代谢酶及转运体的活性及其表达,进而影响药物的非肾清除。因此,本文将就慢性肾疾病对肝和肠道药物代谢酶和转运体影响的相关研究及产生这种影响的相关尿毒症毒素的最新研究进展做一综述。Chronic kidney disease（CKD） not only influences pharmacokinetics and pharmacodynamics of drugs primarily excreted by the kidney but also affect the non-renal disposition of drugs. CKD can alter the expression and activity of intestinal,hepatic drug enzymes and transporters leading to alteration of non- renal clearance of drugs. Thus,the review will summarize the recent progress of the influence of CKD on drug enzymes and transporters,and the relavent uremic toxin producing the influence.

关 键 词：慢性肾疾病 代谢酶 转运体 尿毒症毒素 

分 类 号：R97[医药卫生—药品]