基于Ugi多组分反应的海藻酸酰胺衍生物改性二氧化硅纳米粒子的制备  

Synthesis of Amidic Alginate Derivatives Modified Silica Nanoparticles via Ugi Multicomponent Reaction

作　　者：颜慧琼[1] 陈秀琼[1] 李嘉诚[2] 冯玉红[2] 伍剑博 林强[1] 史载峰[1] 王向辉[1] 

机构地区：[1]海南师范大学化学化工学院,海口571158 [2]海南大学材料与化工学院,海口570228

出　　处：《高等学校化学学报》2016年第5期1018-1024,共7页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:21366010;21566009);海南省重点科技计划项目(批准号:ZDXM2014037)资助~~

摘　　要：采用海藻酸酰胺衍生物通过Ugi多组分反应制备了新颖的聚合物-二氧化硅（Oct-Alg-Si O_2）纳米粒子.通过氢核磁共振波谱（1H NMR）和X射线光电子能谱（XPS）对Oct-Alg-Si O_2的结构和表面元素组分进行了表征.采用透射电子显微镜（TEM）、Zeta电位和激光粒度分析仪对Oct-Alg-Si O_2的形貌、粒径和胶体性能进行了探索.结果表明,海藻酸酰胺衍生物共价接枝到氨基二氧化硅（Si O_2-NH_2）纳米粒子的表面,提高了其平均直径,调控了其Zeta电位,在水介质中能够表现出良好的分散稳定性.以10%的液体石蜡为油相,采用Oct-Alg-Si O_2制备了Pickering乳液.在油水界面能够形成液滴粒径为5.7μm的稳定Pickering乳液.随着水相p H值的增大,乳液体积分数增大,稳定性增强.细胞相容性实验结果表明,Oct-Alg-Si O_2纳米粒子具有极好的生物相容性.To wider applications of silica（ Si O_2） nanoparticles,the Ugi multicomponent reaction was proposed to prepare the novel polymers-silica（ Oct-Alg-Si O_2） nanoparticles using amidic alginate derivatives. The structure and surface elemental composition of Oct-Alg-Si O_2 were confirmed by1 H Nuclear Magnetic Resonance（1H NMR） spectrometer and X-ray photoelectron spectroscopy（ XPS）. Additionally,the morphology,size and colloid stability of Oct-Alg-Si O_2 were also investigated via transmission electron microscope（ TEM）,zeta potential and laser particle size analyzer. The characterization of the materials revealed that Oct-Alg-Si O_2 nanoparticles were successfully fabricated via the Ugi reaction. The amidic alginate derivatives were covalently bonded onto the surface of amino-functionalized silica（ Si O_2-NH_2） nanoparticles,increasing their average diameter and tuning their zeta potential, which could exhibit good dispersion stability performance in the aqueous media. The Pickering emulsions were prepared by Oct-Alg-Si O_2 using 10% liquid paraffin as the oil phase. It is worth noting that the stable Pickering emulsions with an average size of 5. 7 μm could form between the oil-water interfaces. With the increase of p H value,the volume fraction of the emulsions increased and the stability of the emulsions also improved. The cytocompatibility experimental results showed that Oct-Alg-Si O_2 nanoparticles possessed excellent biocompatibility. Oct-Alg-Si O_2 nanoparticles combined excellent colloid stability performance of Si O_2 nanoparticles and good biological properties of amidic alginate derivatives,possessing great potentials in biomedical applications.

关 键 词：Ugi多组分反应 二氧化硅纳米粒子 两亲性 Pickering乳液 海藻酸酰胺衍生物 

分 类 号：O631.3[理学—高分子化学] O621.259.4[理学—化学]