二甲双胍在非小细胞肺癌的预防及治疗中的作用  

Role of metformin in prevention and treatment of non-small cell lung cancer

作　　者：赵黎[1] 胡良安[1] 

机构地区：[1]重庆医科大学附属第一医院呼吸内科,重庆400016

出　　处：《职业与健康》2016年第7期995-998,1002,共5页Occupation and Health

摘　　要：肺癌是恶性程度较高的肿瘤之一,近年发病率呈上升趋势,治疗效果不尽如人意,死亡率较高。二甲双胍为糖尿病治疗的一线用药,有研究表明,使用二甲双胍与肿瘤死亡率及发病率的降低有关,同时可减慢肿瘤细胞生长速度,增强放化疗对肿瘤细胞的杀伤作用,而且其在逆转化疗药物耐药上也有一定作用。这提示二甲双胍有可能作为一种新型抗肿瘤药物进入肺癌治疗临床使用。作者就二甲双胍对肺癌的作用进行综述。Lung cancer is one of the most fatal cancer with rising incidence rate and mortality rate in recent years,while its treatment effect is not satisfactory.Metformin is the first-line drug to treat type 2 diabetes mellitus.Recent years,several studies reveal that there is a lower incidence and of disease and death from cancer in patients with diabetes mellitus treated with metformin than those treated with other anti-diabetic agents.Metformin also can inhibit tumor cell growth,and increase the tumor cell-killing effect of radiotherapy and chemotherapy.It has been reported that metformin has certain effect on reversing chemotherapy drug resistance.All above,prospects may look promising for the clinical application of metformin as a new type of antitumor drugs.This review outlines and analyzes the influence of metformin on lung cancer.

关 键 词：二甲双胍 非小细胞肺癌 

分 类 号：R181.32[医药卫生—流行病学]