《中医方剂大辞典》中含栀子方剂用药规律分析  

Analysis on composition principles of formulae containing Gardeniae Fructus in dictionary of traditional Chinese medicine prescriptions

作　　者：胡燕珍 卫军营[2] 唐仕欢[2] 杨洪军[2] 

机构地区：[1]江西中医药大学药学院,江西南昌330004 [2]中国中医科学院中药研究所,北京100700

出　　处：《中国中药杂志》2016年第7期1342-1347,共6页China Journal of Chinese Materia Medica

基　　金：国家"十二五"科技支撑计划课题(2011BAI04B01);中医药行业科研专项(200907001-5)

摘　　要：栀子为药食两用的物品,不仅在中医临床中经常使用,在食品与保健食品中也应用广泛。《中医方剂大辞典》是中医方剂的集大成者,为方剂与中药的开发研究提供了良好素材。该文基于中医传承辅助平台(TCMISS),分析《中医方剂大辞典》中含栀子方剂组方规律,为栀子的临床应用及深度研发提供参考。应用TCMISS将含栀子方剂构建数据库,使用该软件的频次统计、关联规则等数据处理方法,分析含栀子方剂中的常用药物、组合规律、核心组合。共纳入方剂3 523首,涉及中药1 725味,设支持度352(10%)、置信度90%,共得到在含栀子方剂中出现频次较高的药物组合57对,核心组合用药较为集中,组方法度清晰;主治疾病18种。其中,栀子常与清热解毒、祛风解表、活血行气、活血化瘀之品联用,主以黄疸、伤寒、头痛等为治疗病症。Gardeniae Fructus,which is widely used in health foods and clinical medicines,is a type of edible food and medicine.Dictionary of traditional Chinese medicine prescriptions provides good materials for prescription analysis and the RD of traditional Chinese medicines. The composition regularity of formulae containing Gardeniae Fructus in dictionary of traditional Chinese medicine prescriptions was analyzed on the basis of the traditional Chinese medicine inheritance support system（ TCMISS）,in order to provide reference for clinical application and the RD of new drugs. TCMISS was applied to establish a database of prescriptions containing Gardeniae Fructus. The software＇s frequency statistics and association rules and other date mining technologies were adopted to analyze commonly used drugs,combination rules and core combined formulae containing Gardeniae Fructus. Totally 3 523 prescriptions were included in this study and involved 1 725 Chinese herbs. With a support degree of 352（ 10%） and confidence coefficient of 90%,57 most commonly used drug combinations were screened. Drugs adopted in core combinations were relatively concentrated and selected according to definite composition methods. They were used to mainly treat 18 diseases. Gardeniae Fructus have often been combined with herbs for heat-clearing and detoxification,expelling pathogenic wind,relieving exterior syndrome,invigorating the circulation of blood and gas and promoting blood circulation for removing blood stasis to mainly treat jaundice,typhoid,headache and other syndromes.

关 键 词：《中医方剂大辞典》 栀子 中医传承辅助平台 组方规律 

分 类 号：R289.1[医药卫生—方剂学]