人类血小板特异性抗原及其与特发性血小板减少性紫癜相关性研究进展  

Advances on the correlation between human platelet antigen and idipathic thrombocytopenic purpura

作　　者：唐利娟[1] 周晓恒[1] 宾琼[1] 罗建明[1] 

机构地区：[1]广西壮族自治区民族医院广西医科大学附属民族医院,广西南宁530001

出　　处：《中国输血杂志》2016年第3期326-329,共4页Chinese Journal of Blood Transfusion

摘　　要：人类血小板特异性抗原(HPA)是表达于不同血小板膜糖蛋白(GP)上的抗原表位,是血小板外膜上特有的抗原决定簇。HPA的种族差异性可导致血小板同种免疫性疾病发生。特发性血小板减少性紫癜(ITP)是一种相当普遍的出血性疾病,目前认为其发病机制与同种免疫反应有关。本文介绍了HPA的命名、定位、分子学生物特征,与之相关的血小板膜糖蛋白,综述了国内外HPA基因多态性与ITP发病相关性研究。Human platelet antigen （HPA）systems are epitopes expressing on different platelet membrane glyeoproteins （GPs） and are specific antigenic determinant of platelets. Ethnic differences in HPA may lead to alloimune thrombocytopenia. Idiopathic thrombocytopenie purpura （][TP） is a quite common hemorrhagic disease. It is believed that the pathogenesis of ITP is associated with an alloimmune response. This review introduces the nomenclature, location, molecular biological charaeteris- ties of HPA and relevant platelet membrane GPs, and summarizes the studies conducted on correlation between genetic poly- morphisms and the pathogenesis of ITP.

关 键 词：HPA 血小板膜糖蛋白 特发性血小板减少性紫癜 

分 类 号：R457.1[医药卫生—治疗学] R558.2[医药卫生—临床医学]