不同浓度氨基酮戊酸光动力治疗囊肿痤疮疗效观察  

Photodynamic therapy with different concentrations of 5-aminolevulinic acid in the treatment of cystic acne

作　　者：郭晓兰[1] 邓列华[2] 杨文彪[1] 黄芳仪[1] 欧阳志彬[1] 

机构地区：[1]中山大学附属江门中心医院皮肤科,江门529030 [2]暨南大学第一附属医院皮肤科

出　　处：《实用皮肤病学杂志》2016年第2期112-114,共3页Journal of Practical Dermatology

摘　　要：目的探索5-氨基酮戊酸光动力疗法(ALA-PDT)治疗囊肿痤疮时5-氨基酮戊酸(ALA)的最适浓度。方法采用随机方法将116例囊肿痤疮患者分为3个治疗组,给予ALA的浓度分别为5%、7.5%、10%,均采用波长632.8 nm的红光照射,每周1次,共4次。结果在治疗结束后2周、1个月、3个月,7.5%和10%浓度组间疗效差异均无统计学意义(P均>0.05),而这两组与5%浓度组比较,差异均有统计学意义(P均<0.05)。不良反应为红斑、肿胀,部分患者出现轻微渗出及暂时性色素沉着,所有患者均未出现溃疡和瘢痕。结论结合临床有效率及安全性,ALA-PDT治疗囊肿痤疮宜采用7.5%的浓度。Objective To investigate the optimal concentration of 5-aminolevulinic acid photodynamic therapy（ALA-PDT） for cystic acne. Methods Total 116 patients were randomly divided into 3 groups to be applied with ALA-PDT in different concentrations（5%, 7.5% and 10%）. The patients were treated with red light of 632.8 nm once a week for 4 procedures. The subsidence of lesions was evaluated by dermatologist at the baseline and after half a month, 1 and 3 month of the last treatment. Adverse reactions were recorded at follow-up. Results Half a month, one month and three months after the last treatment, there was no significant difference between 7.5% and 10% group（P〉0.05）. Compared with 5% group, there were signifi cant differences between the every two groups with the different concentrations（P〈0.05）. Side effects included erythema, swelling, a little of exudation and transient pigmentation. Neither ulceration nor scarring was noted. Conclusion In view of effectiveness and safety, ALA with concentration of 7.5% is recommended for the treatment of cystic acne.

关 键 词：痤疮 囊肿 5-氨基酮戊酸光动力疗法 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]