炎症在颅内动脉瘤形成和破裂中的作用和机制  

Roles and mechanism of inflammation in intracranial aneurysm formation and rupture

作　　者：姚鹏飞[1] 程刚[1] 高晨[1] 

机构地区：[1]兰州军区兰州总医院安宁分院神经外科,730070

出　　处：《国际脑血管病杂志》2016年第3期275-278,共4页International Journal of Cerebrovascular Diseases

基　　金：甘肃省科技计划项目(1506RJZA304) Fund program:Science and Technology Planning Project of Gansu Province of China

摘　　要：炎症参与了许多血管性疾病的发病过程。血流动力学引起血管壁炎性因子激活，导致血管内皮细胞和血管平滑肌细胞功能障碍，激活血管壁炎性级联反应。炎性细胞，尤其是巨噬细胞浸润并分泌的酶类逐渐使血管壁薄弱形成动脉瘤甚至导致其破裂。因此，炎症在颅内动脉瘤的形成和破裂中发挥着关键作用。Inflammation is involved in the pathogenesis of many vascular disorders. Hemodynamics cause the activation of inflammatory factors in the vascular wal , resulting in dysfunction of vascular endothelial cels and vascular smooth muscle cels, activating vascular wal inflammatory cascade. Inflammatory cels, especialy macrophage infiltration and secretion of enzymes gradualy weaken the vessel wal to form aneurysm, and even cause aneurysm rupture. Therefore, inflammation plays a key role in the formation and rupture of intracranial aneurysms.

关 键 词：颅内动脉瘤 动脉瘤 破裂 炎症 

分 类 号：R743[医药卫生—神经病学与精神病学]