口服避孕药预处理对长效长方案体外受精-胚胎移植临床结局的影响  

The effect of oral contraceptive pill pretreatment on clinical outcome in patients with long-acting form of gonadotrophin releasing-hormone agonist long protocol

作　　者：董哲 孙玲 尹敏娜 

机构地区：[1]广州市妇女儿童医疗中心生殖医学中心,广东广州510623

出　　处：《中国计划生育和妇产科》2016年第5期24-28,共5页Chinese Journal of Family Planning & Gynecotokology

基　　金：广州市医药卫生科技一般引导项目资助基金(编号:20141A011032)

摘　　要：目的探讨口服避孕药(oral contraception pill,OCP)前期预处理对接受长效长方案控制性超排卵患者临床结局的影响。方法对2011年1月至2013年4月在广州市妇女儿童医疗中心生殖医学中心进行长效长方案治疗的正常卵巢储备患者325例的临床资料进行分析。采用OCP前期预处理的185例患者为OCP组,未采用OCP预处理140例患者为对照组。比较两组卵巢过度刺激综合征(ovarian hyperstimulation syndrome,OHSS)发生率、促性腺激素用量与天数、获卵数、临床妊娠率、着床率。结果 OCP组OHSS发生率(5.9%)高于对照组(1.4%)(P<0.05);两组间促性腺激素的用量、获卵数、临床妊娠率、着床率比较差异无统计学意义(P>0.05)。结论长效长方案治疗中,OCP预处理可能增加了正常卵巢储备患者OHSS的发生率。Objective To evaluate the effects of oral contraception pill （OCP） pretreatment on clinical outcome of patients with long - acting form of gonadotrophin releasing - hormone agonist （ GnRH - a） long protocol. Methods The clinical data of 325 patients undergone in - vitro fertilization （IVF） in Reproductive Medicine Center of Guangzhou Women and Children＇ s Medical Center from January 2011 to April 2013 were analyzed retrospectively. Among them, 185 patients treated with OCP （Marvelon） were set as OCP group, and 140 patients received gonadotropin -releasing hormone agonist（ GnRH - a） down regulation after spontaneous ovulation were set as control group. Occurrence rate of ovarian hyperstimulation syndrome （ OHSS ） , the duration and amount of gonadotropin used, number of retrieved oocytes, clinical pregnancy rate and implantation rate of two groups were compared. Results The incidence rate of OHSS in OCP group was higher than that in control group （P 〈 0. 05 ） , the duration and amount of gonadotropin used, number of retrieved oocytes,fertilization rate, clinical pregnancy rate and implantation rate had no statistical difference between the two groups （P 〉 0.05）. ConclusionsPretreatment with an OCP could increase the incidence of OHSS in patients with normal ovarian reserve who accepted long - acting form of GnRH - a long protocol.

关 键 词：口服避孕药 预处理 体外受精-胚胎移植 长效长方案 

分 类 号：R713.7[医药卫生—妇产科学]