几类N-氧化物的应用和直接合成方法  

Applications and direct synthesis approaches of several kinds of N-oxides

作　　者：易亮[1] 孙德群[1] 

机构地区：[1]山东大学(威海)海洋学院,威海264209

出　　处：《四川大学学报（自然科学版）》2016年第3期606-625,共20页Journal of Sichuan University(Natural Science Edition)

基　　金：国家863计划(2012AA020306)

摘　　要：N-氧化物是一类具有广泛生物活性的化合物,常用于各种药物合成的中间体或者本身就是药物;同时它们也可以作为有机化工中间体和催化剂等,在有机合成上起到非常重要的作用.传统的制备N-氧化物的方法是采用合适的氧化剂对含氮化合物进行N-氧化.此外,用直接合成方法,即在生成含氮化合物的同时发生N-氧化,也可以得到相应的N-氧化物.由于直接合成方法的一些优势和传统方法的诸多缺陷,本文着重总结了包括嘧啶类N-氧化物和喹喔啉类N-氧化物等在内的十类N-氧化物的直接合成方法,并简述了它们的应用.N-oxides are a class of compounds with a wide range of biological activity,commonly used as drugs or various pharmaceutical synthesis intermediates;In addition,they also can be used as organic chemical intermediates or catalyst and play a very important role in organic synthesis.The traditional approaches to prepare N-oxides is via oxidation of nitrogen in nitrogen-containing compounds with suitable oxidant.Besides,by direct synthesis approaches,namely generating the nitrogen-containing compounds,the N-oxidation occurs simultaneously,can also to give the corresponding N-oxides.Considering the advantages of direct synthesis approaches and the disadvantages of traditional approaches,this paper especially summarized the direct synthesis approaches of ten kinds of N-oxides,such as pyrimidine N-oxides and quinoxaline N-oxides,etc.Further more,the applications of the ten kinds of N-oxides were described.

关 键 词：N-氧化物 药物 有机合成 直接合成方法 

分 类 号：O623.7[理学—有机化学] O626[理学—化学]