组胺H_3受体参与低氧调控的研究进展  

Role of histamine H_3 receptor in regulation of hypoxia

作　　者：廉靖靖 颜玲娣[2] 周培岚[2] 苏瑞斌[1,2] 

机构地区：[1]广西医科大学药学院,广西南宁530021 [2]军事医学科学院毒物药物研究所,抗毒药物与毒理学国家重点实验室,北京100850

出　　处：《中国药理学与毒理学杂志》2016年第4期369-374,共6页Chinese Journal of Pharmacology and Toxicology

基　　金：国家科技重大专项(2012ZX09301-001-006)

摘　　要：低氧是指机体供氧不足或用氧障碍,栓死、一氧化碳中毒和阻塞性呼吸睡眠等多种病理过程均与低氧相关。高原地区特有的低氧环境会使人因供氧不足而产生急性高原反应,甚至高原肺水肿和脑水肿。组胺H3受体广泛分布于中枢及外周组织,主要作为突触前膜受体,调控组胺及多巴胺、乙酰胆碱等多种神经递质的释放。低氧条件下组胺H3受体可分别于颈动脉体及呼吸中枢延髓参与呼吸活动的调控。此外,组胺能系统在中枢参与低血低氧性脑损伤调控,其中组胺H3受体发挥了重要作用。本文就组胺H3受体的结构特征、功能及其参与低氧调控的可能机制做一综述,阐述靶向组胺H3受体研发抗低氧药物的可能性。;Hypoxia refers to the reduction in tissue oxygen supply or utilization. It occurs in various pathological symptoms like embolism,anthracemia,and chronic obstructive sleep. At high altitude,lower partial pressure of oxygen compromises the supply of adequate oxygen to the tissues and leads to many clinical syndromes,such as acute mountain sickness,high-altitude cerebral edema,and highaltitude pulmonary edema. Histamine H3 receptor,primarily as a presynaptic receptor,is widely expressed in the central and peripheral systems. Histamine,dopamine,acetylcholine and many other neurotransmitters are regulated by histamine H3 receptor. Studies have shown that histamine H3 receptor is involved in the hypoxic response of the respiratory network. In addition,histamine,especially histamine H3 receptor,participates in the regulation of cerebral ischemia in the central nervous system. In this paper,we reviewed the structure and functions of histamine H3 receptor and explained its role in the regulation of hypoxia so as to evaluate the possibility of histamine H3 receptor as a drug target for the therapy of hypoxia-induced injuries.

关 键 词：组胺 组胺H3受体 低氧 

分 类 号：R96[医药卫生—药理学]