纳米材料诱导细胞死亡的研究进展  

Cell death induced by nanomaterials:research progress

作　　者：贾健[1] 李艳博[1] 郭彩霞[1] 

机构地区：[1]首都医科大学公共卫生学院,北京100069

出　　处：《中国药理学与毒理学杂志》2016年第4期421-428,共8页Chinese Journal of Pharmacology and Toxicology

基　　金：国家自然科学基金青年项目(81102095);国家自然科学基金青年项目(81202242);国家自然科学基金青年项目(81573176);北京市教育委员会科技发展计划面上项目(KM201510025005);北京高等学校青年英才计划项目(YETP1670)~~

摘　　要：随着纳米材料在生物医药、材料化工等众多领域日益广泛的应用,纳米材料环境暴露及其引发的细胞毒性效应受到了研究人员的高度关注,成为纳米毒理和纳米医药研究领域中一个新的研究方向。纳米材料的毒性作用研究不仅为纳米材料的安全性评价提供了理论依据,而且有助于进一步扩展纳米技术的应用领域。本文重点阐述纳米材料在细胞自噬、凋亡和坏死中的作用,并探讨纳米材料诱导不同细胞死亡方式的可能机制,为纳米材料的毒性研究和安全性评价提供参考。With the wide use of nanomaterials in biomedicine,materials,chemicals and other fields,their environmental exposure and cellular toxicity have come to the attention of researchers as a new research area in the field of nanotoxicology and nanomedicine. Researches on the toxic effects of nanomaterials have not only provided of a theoretical basis for safety evaluation of nanomaterials,but also promoted the have applications of nanotechnology. Numerous studies have revealed cell death is closely associated with the toxicity of nanomaterials. In this paper,we elaborated on the roles of three key cell death modes in nanotoxicity,including autophagy,apoptosis,and necrosis. Furthermore,the possible mechanisms involved in these three modes were explored. All this will provide reference for safety evaluation of nanomaterials.

关 键 词：纳米材料 细胞死亡 细胞凋亡 自噬 坏死 

分 类 号：R318.08[医药卫生—生物医学工程] TB383.1[医药卫生—基础医学]