天然高分子材料及其衍生物制备组织工程真皮支架的研究进展  

Advances in the research of natural polymeric materials and their derivatives in the manufacture of scaffolds for dermal tissue engineering

作　　者：李冉[1] 汪虹[1] 冷崇燕[2] 王宽[1] 解英[1] 

机构地区：[1]昆明医科大学第二附属医院烧伤科,云南省烧伤研究所,650101 [2]昆明理工大学材料科学与工程学院

出　　处：《中华烧伤杂志》2016年第5期316-318,共3页Chinese Journal of Burns

基　　金：云南省卫生科技计划（2014NS065）

摘　　要：理想的皮肤替代物一直是医学界研究的热点和需要解决的难题，组织工程技术的兴起和快速发展为皮肤缺损的修复提供了新思路。体外构建组织工程化皮肤的关键是种子细胞赖以生存的支架，其中天然高分子材料及其衍生物近年来被广泛用于制备支架。天然高分子材料及其衍生物是可从生物体内提取或从自然环境中直接得到的一类生物大分子，抗原性较弱，不易引起免疫排斥反应，且可诱导、调节细胞的生长和分化，同时应用其制作的支架具备利于种子细胞增殖、迁移的三维立体结构及适合种子细胞大小的孔隙；另其来源丰富、造价低廉，在理化性能及生物降解性等方面也显著优于人工合成材料。Natural polymeric materials and their deriva- tives are organic maeromolecular compounds which exist in plants, animals, and micro-organisms. They have been widely used in the preparation of scaffolds for skin tissue engineering re- cently because of their good histoeompatibility and degradability, and low immunogenicity. With the improvement of the prepara- tion technics, composite materials are more commonly used to make scaffolds for dermal tissue engineering. This article sum- marizes the classification and research status of the commonly used natural polymer materials, their derivatives, and composite scaffold materials, as well as makes a prospect of the research trends of dermal scaffold in the future.

关 键 词：皮肤 组织工程 天然高分子材料 衍生物 真皮支架 

分 类 号：R318.08[医药卫生—生物医学工程]