哈尔滨市定点治疗机构艾滋病患者抗病毒治疗概况及影响因素分析  

Efficacy of antiretroviral therapy and influencing factors for people living with HIV/AIDS in designated hospitals in Harbin

作　　者：赵鹏宇[1] 于鑫[1] 杨凯[1] 冯世燕 王福祥[2] 王滨有[1] 

机构地区：[1]哈尔滨医科大学公共卫生学院,150081 [2]哈尔滨医科大学附属第四医院感染科,150000

出　　处：《中华流行病学杂志》2016年第5期634-637,共4页Chinese Journal of Epidemiology

基　　金：黑龙江省自然基金（H201383）

摘　　要：目的了解艾滋病抗病毒治疗情况及影响因素，为提高患者治疗效果和生存质量提供科学依据。方法2014年9月至2015年5月采用横断面研究，收集和整理黑龙江省哈尔滨市艾滋病定点治疗机构接受艾滋病抗病毒治疗243例患者相关信息，使用SAS9．2统计软件分析，Excel 2010软件绘图。单因素分析使用t检验，多因素分析采用有序logistic回归，CD4＋T淋巴细胞计数的比较使用Wilcoxon秩和检验。结果艾滋病抗病毒治疗人数呈上升趋势，感染的原因主要为同性性传播，经6个月及以上的抗病毒治疗CD4＋T淋巴细胞计数水平有不同程度增长（P〈0．01）。家庭人均月收入（P〈0．05），是否更换过抗病毒治疗方案（P〈0．05），社会关系领域（P〈0．05），经济费用担忧（P〈0．01），服药依从性（P〈0．01）及抗病毒治疗前CD4＋T淋巴细胞水平（P〈0．01）均是影响抗病毒治疗效果的因素，具有统计学意义。结论哈尔滨市定点治疗机构的艾滋病抗病毒治疗人数持续上升，抗病毒治疗效果明显。Objective To understand the efficacy of antiretroviral therapy for people living with HIV/AIDS and influencing factors; and provide evidence to improve the treatment of HIV infection and AIDS for the better life of the patients. Methods A cross sectional study was conducted in designated AIDS hospitals in Harbin. A questionnaire was used to collect the information of the patients receiving treatment in these hospitals. The statistical analysis was done with software SAS 9.2 and Excel 2010. Univariate analysis was performed with t test and multivariate analysis was performed with ordinal logistic regression model. Wilcoxon ranks sum test was conducted to compare the CD4＋ T lymphocyte counts. Results The number of the patients receiving antiretroviral therapy was in increase in recent years. The HIV infection route was mainly homosexual contact. The CD4 ＋T lymphocyte count of the patients increased at different levels after ≥6 months treatment （P〈0.01）. Household income （P〈0.05）, adherence to treatment plan or not （P〈0.05）, social relationship （P〈0.05）, concern of economic cost （P〈0.01） medication compliance （P〈0.01） and initial level of CD4 ＋ T lymphocyte （P〈0.01） were the influencing factors for antiretroviral therapy efficacy. Conclusion In designated hospitals in Harbin, the number of the patients receiving HIV antiretroviral therapy kept to increase and the efficacy of the treatment was obvious.

关 键 词：艾滋病病毒感染者/艾滋病患者 抗病毒治疗 治疗效果影响因素 

分 类 号：R512.91[医药卫生—内科学]